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@article{ART001086508},
author={박동수 and Kim， Soon-joong and Seo,Il-bok and Jeong， Su-hyeon},
title={Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2007},
volume={17},
number={3},
pages={1-18}

TY - JOUR
AU - 박동수
AU - Kim， Soon-joong
AU - Seo,Il-bok
AU - Jeong， Su-hyeon
TI - Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model
JO - Journal of Korean Medicine Rehabilitation
PY - 2007
VL - 17
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 1
EP - 18
SN - 1229-1854
AB - Objectives : This study was carried out to investigate the effects of Bee-venom treatment on the expression of NOS, c-fos, serotonin and substance P in central nerve system of monosodium iodoacetate(MIA)-induced osteoarthritic pain model. Methods : Arthritis was induced by injection of MIA(0.5mg) into knee joint cavities of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was injected with normal saline once a day for 20 days, while treated group was injected with Bee-venom extract once a day for same duration. Injected point of Bee-venom and saline was subcutaneous tissue at Tokpi(ST35) acupoint. Histochemical study of NADPH-d and immunohistochemical study of c-fos, serotonin and substance P in brain and spinal cord were performed at 20 days after MIA injection. Results : 1. The numbers of NADPH-d positive cells in superficial dorsal horn of spinal cord of treated group(24±4) was significantly (p<0.01) decreased compared with control(33±5). The numbers of NADPH-d positive cell in dorsolateral periaqueductal gray matter of treated group(114±18) was significantly(p<0.01) decreased compared with control(143±14). 2. The numbers of c-fos positive cells in dorsal periaqueductal gray matter of treated group(56±8) was significantly(p<0.01) decreased compared with control(78±13). The numbers of c-fos positive cells in paraventricular thalamic nucleus of treated group(64±14) was significantly decreased compared with control(88±27). 3. The numbers of serotonin positive cells in median raphe nucleus of treated group(104±15) was significantly(p<0.05) decreased compared with control(139±34). Conclusions : On the basis of these results, we concluded that Bee-venom treatment has inhibiting effects on the pain transmission in monosodium iodoacetate-induced osteoarthritic pain model in rat.
KW - Monosodium iodoacetate;Osteoarthritis;Bee-venom;pain;NADPH-d;C-fos;Serotonin
DO -
UR -
ER -

박동수, Kim， Soon-joong, Seo,Il-bok and Jeong， Su-hyeon. (2007). Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model. Journal of Korean Medicine Rehabilitation, 17(3), 1-18.

박동수, Kim， Soon-joong, Seo,Il-bok and Jeong， Su-hyeon. 2007, "Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model", Journal of Korean Medicine Rehabilitation, vol.17, no.3 pp.1-18.

박동수, Kim， Soon-joong, Seo,Il-bok, Jeong， Su-hyeon "Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model" Journal of Korean Medicine Rehabilitation 17.3 pp.1-18 (2007) : 1.

박동수, Kim， Soon-joong, Seo,Il-bok, Jeong， Su-hyeon. Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model. 2007; 17(3), 1-18.

박동수, Kim， Soon-joong, Seo,Il-bok and Jeong， Su-hyeon. "Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model" Journal of Korean Medicine Rehabilitation 17, no.3 (2007) : 1-18.

박동수; Kim， Soon-joong; Seo,Il-bok; Jeong， Su-hyeon. Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model. Journal of Korean Medicine Rehabilitation, 17(3), 1-18.

박동수; Kim， Soon-joong; Seo,Il-bok; Jeong， Su-hyeon. Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model. Journal of Korean Medicine Rehabilitation. 2007; 17(3) 1-18.

박동수, Kim， Soon-joong, Seo,Il-bok, Jeong， Su-hyeon. Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model. 2007; 17(3), 1-18.

박동수, Kim， Soon-joong, Seo,Il-bok and Jeong， Su-hyeon. "Effects of Bee-venom Treatment on the Expression of NOS, C-fos, Serotonin and Substance P in Central Nerve System of Monosodium Iodoacetate-induced Osteoarthritic Pain Model" Journal of Korean Medicine Rehabilitation 17, no.3 (2007) : 1-18.