Effects of Samul-tang(Siwu-tang) with Puerariae Radix on Ovariectomized Osteoporotic Rat Models (四物湯加葛根이 卵巢摘出로 誘發된 흰쥐의 骨多孔症에 미치는 영향)

Jeonghwan Kim (김정환); Shin, Byung Cheul (신병철); Seung-ryong Yeom (염승룡); Young Dal Kwon (권영달); SONG YUNG SUN (송용선); 정순관; 길은영

Effects of Samul-tang(Siwu-tang) with Puerariae Radix on Ovariectomized Osteoporotic Rat Models

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2007, 17(4), pp.89-105
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

Jeonghwan Kim ¹, Shin, Byung Cheul ², Seung-ryong Yeom ³, Young Dal Kwon ³, SONG YUNG SUN ³, 정순관 ³, 길은영 ³

¹우석대학교
²부산대학교
³원광대학교

Candidate

ABSTRACT

Objectives : The aim of this study was to identify whether Samul-tang(Siwa-tang) with Puerariae radix extracts (SMG) induced inhibiting activity on the resorption of bone in ovariectomized (OVX) rats. Methods : Adult female rats as an in vivo animal model was selected and forty were randomly assigned equally into four groups: normal control group; OVX group; OVX + SMG 1,250 mg/kg/day (T1); OVX + SMG 2,500 mg/kg/day (T2). Ten days after operation first two groups were treated with normal saline, T1 and T2 group with SMG for 7weeks, respectively. Results : 1. SMG significantly suppressed the increase of weight and abdominal fat of OVX rats. 2. Plasma LDL-cholesterol levels were significantly decreased following weeks. 3. Administration of SMG had a tendency to increase the bone meneral density in OVX rats. 4. SMG improved loss of trabeculae, increase of fat cell, osteoclast and uterus atrophy of OVX rats. Conclusions : These results propose the possibility that estrogenic traditional herb medicine such as SMG can be one of candidates for the treatment or prevention of osteoporosis.

KEYWORDS

osteoporosis, Samul-tang(Siwa-tang), Puerariae Radix, Ovariectomy

Citation status

* References for papers published after 2023 are currently being built.

[journal] / 2002 / 한의부인과학 上 / 서울:정담 : 240~

[journal] / 2006 / 골다공증(Osteoporosis) / 서울:한미의학 : 11~203

[journal] / 2005 / 폐경후 골다공증의 최신치료 48(4) : 844~856

[journal] / 1998 / 東醫方劑와 處方解說 / 서울:의성당 : 167~

[journal] / 1999 / 보중익기탕과 사물탕이 골다공증에 미치는 임상적 연구 9(1) : 59~74

[journal] / 2006 / Pueraria radix prometes differentiation and mineralization in human osteoblast-like SaOS-2 cells 104 : 345~350

[journal] / 2005 / Puerariae radix prevents bone loss in castrated male mice 54 : 1536~1541

[journal] / 2002 / Effects of genistein and hormone-replacement therapy on bone loss in early post-menopausal women: a randomized double-blind placebo controlled study 17 : 1904~1912

[journal] / 2003 / Puerariae radix prevents bone loss in ovariectomized mice 21 : 268~275

[journal] 김정숙 / 2002 / Pueraria lobata Ohwi as an Osteoporosis Therapeutics 34(4) : 710~718

[journal] Ishimi Y / 2000 / Differnce in effective dosage of genistein on bone and uterus in ovariectomized mice 274 : 697~701

[journal] Wu J / 2001 / Cooperative effects of exercise training and genistein daministration on bone mass in ovariectomized mice 16 : 1829~1836

[journal] Shin J / 2006 / Estrogenic effect of main components kakkalide and tectoridin of puerariae flos and their metabolites. Biol Pharm Bull 29(6) : 1202~1206

[journal] Kaufman PB / 1997 / A comparative survey of leguminous plants as sourecs of the isoflavones, genistein and daidzein: implications for human nutrition and health 3(1) : 7~12

[journal] 김소정 / 2004 / A Study on the Estrogenicity of Korean Arrowroot (Pueraria thunbergiana) 33(1) : 16~21

[journal] 강병문 / 2006 / 골다공증 치료의 의학약제와 대체약물의 비교 49(2) : 2459~2473

[journal] Lydeking-Olsen E / 2004 / Soy milk or progesterone for prevention of bone loss - a 2 year randomized placebo-controlled trial 43 : 246~257

[journal] Saloniemi H / 1995 / Phytoestrogen content and estrogenic effect of legume fodder 208 : 13~17

[journal] / 1998 / Phytoestrogens: where are we now? 79 : 393~406

[journal] / 1998 / Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β 139 : 4252~4263

[journal] / 1993;342 / Plasma concentrations of Phytoestrogens in Japanese men : 1209~10

[journal] / 2001 / 黃帝內經素問 / 서울:여강출판사 : 31~38

[journal] / 1999 / 東醫寶鑑國譯委員會譯. 對譯東醫寶鑑 / 서울:법인문화사 : 1168~

[journal] / 1997 / 사물탕과 육미지황탕이 난소적출로 유발된 백서의 골다공증에 미치는 영향 1(1) : 31~48

[journal] / 1999 / 보중익기탕과 사물탕이 골다공증에 미치는 임상적 연구 9(1) : 59~74

[journal] / 1972;55 / Osteoporosis after rat and the effect of estrogen and/or progestogen replacement therapy in its prevention : 79~87

[journal] / 1994;25 / Effects of ovariectomy and estrogen on the serum levels of insulin-lilke growth factor-I and insulin-lilke growth factor binding protein-3 : 135~47

[journal] / 1980;50 / Relationship of fasting urinary calcium to circulating estrogen and body weight in postmenopausal women j clin endocri(l metab) : 70~5

[journal] / 1995 / Evaluation of the pathogenesis of postmenopausal bone loss 17 : 135S~144S

[journal] / 1992;27 / 백서의 난소제거술후 발생한 골조송증에 대한 Calcitonin의 효과 : 577~82

[journal] / 1998 / Selective estrogen receptor modulators: an alternative to hormone replacement therapy 217 : 45~52

[journal] / 1994;1 / 골형성의 생화학적 표지자 : 233~9

[journal] / 1998 / 내분비질환의 진단과 치료 / 서울:한국의학 : 341~351

[journal] / 1997 / 골다공증 검진 방법에 대한 소고 7(1) : 244~253

[journal] / 2003 / Soy isoflavones have favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind randomized controlled trial 88 : 4740~4747

[journal] / 2004 / The effect of soy protein isolate on bone metabolism 11 : 290~298

[journal] / 2003 / Evidence of estrogenic effect by the three-month intervention of isoflavone on vaginal maturation and bone metabolism on early postmenopausal women 50 : 613~619

KJCKorea
Journal Central

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6