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The Study on Antioxidative Effect of Mori Folium and Effect on Cytokines to 3T3-L1 Cell Lines

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2007, 17(4), pp.75-87
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

편기욱 1 Cha Yun Yeop 1

1상지대학교

Candidate

ABSTRACT

Objectives : The aim of this study was to find out antioxidative effect of Mori Folium and effect on cytokines to 3T3-L1 Cell Lines. Methods : For this purpose, Mori Folium was used for 4 methods, those were DPPH radical scavenging activity, Nitric oxide(NO) radical scavenging activity, Superoxide anion radical scavenging activity and Bovine Serum albumin(BSA). And in order to investigate the effect of Mori Folium on immunologic control function, the various cytokines responses were studied. Results : 1. In experiment on DPPH radical scavenging activity, we experienced that the ability of DPPH radical's elimination was increased by rising Cocentration of Mori Folium.(CMF). When the CMF was 2.5 mg/ml, the ability of DPPH radical's elimination was maximum. 2. In experiment on Nitric oxide(NO) radical scavenging activity, we founded that the ability of NO radical's elimination was increased by rising CMF.. When the CMF was 1.25 mg/ml, the ability of NO radical's elimination was maximum. 3. We measured level of Superoxide anion radical scavenging activity. And we founded that the ability of Superoxide anion radical's elimination was maximum when CMF was 0.3125 mg/ml. 4. When we inspected antioxidative effects with BSA, we found that ability of defense was increased by rising CMF. When the CMF was 5 mg/ml, the ability of defense was maximum. 5. In experiment, we measured an effect of Mori Folium on differentiation of 3T3-L1 Preadipocytes and gained the increase of cytokines(IL-2, IL-4, IL-12p70, GM-CSF, INF-γ, TNF-α). Conclusions : Mori Folium (mulberry leaves) exhibited significant antioxidative effects, and have effectiveness on immune system.

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