Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
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pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
The Effects of Jeho-tang(Tihutang) and Ganoderma Lucidum Extract on the Recovery of Fatigue in High Intensity Exercise Rats
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2007, 17(4), pp.55-73
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
박지훈 1, Misook Shin 2, 박정현 1, choi jin bong 3, Jeong-Ho Lee 1, 김선종 3
1동국대학교
2부산대학교
3동신대학교
Candidate
ABSTRACT
Objectives :
This study was designed to evaluate the effects of Jeho-tang(Tihutang) and Ganoderma Lucidum extract on the recovery of fatigue induced by treadmill exercise in rats.
Methods :
The rat subjects were divided into 4 groups : Normal, Control with treadmill exercise under 70% max(VO2max) intensity, Experimental Ⅰ(Ex Ⅰ) taken with Jeho-tang during treadmill exercise and Experimental Ⅱ(Ex Ⅱ) taken with Ganoderma Lucidum extract during treadmill exercise. All the serum samples collected by heart puncture were used to measure biomechanical factors such as lactate dehydrogenase(LDH), ammonia, inorganic phosphate, creatine kinase(CK), glucose, lactate, triglycerides(TG), high-density lipoprotein(HDL), low-density lipoprotein(LDL) and total cholesterol(TC). Besides, glycogen concentration and Heat shock protein 70(HSP70) by western blotting were measured. Histopathological changes in liver, kidney and muscle were investigated.
Results :
1. LDH, ammonia, inorganic phosphate and lactate were significantly decreased in the experimental groups as compared with control group(p<0.05).
2. TC and LDL were significantly decreased in the Ex Ⅰ and Ex Ⅱ as compared with control group(p<0.05).
3. The HSP70 expression was increased in all the groups, especially significant in Ex Ⅱ.
Conclusions :
According to the above results, Jeho-tang(Tihutang) and Ganoderma Lucidum extract can recover the fatigue after high intensity exercise. If Jeho-tang (Tihutang) and Ganoderma Lucidum extract can be more useful as ergogenic aids, further studies about their underlying mechanism may be needed.
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