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The Study on the Effects of Dangguicheongung-tang-kamibang(Dangguichuanxiongtangjiaweifang) on the Arthritis

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2006, 16(1), pp.109-126
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

제병선 1 Yoon il ji 2 Minseok Oh 2 박장우 1

1대전대학교
2대전대학교

Candidate

ABSTRACT

Objectives: This study was carried out to investigate the effects of Dangguicheongung-tang-kamibang(Dangguichuanxiongtangjiaweifang;DCT) on the in vitro and in vivo inflammatory reactions. Methods: In experiment, leukocytes were calculated by coulter counter for leukocyte migration, absorbance was measured by ELISA reader for vascular permeability. GRIESS method was used for NO inhibition. RT-PCR was used for inhibition of iNOS expression. Radical scavenging was tested by DPPH method. Results: DCT showed inhibitory effects on leukocyte migration(12.7%) and vascular permeability(25.3%) in animal test. DCT extract inhibited the gene expression of iNOS. In COX-2 inhibition assay, DCT inhibited PGE2 generation(48% at a concentration of 10㎍/㎖), exhibited radical scavenging activity of 48.7% at 100㎍/㎖. Conclusions: These results indicates that DCT has a potent anti-inflammatory prescription.

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