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Acute Toxicity of Fermented Deer Velvet Antler Extract in ICR Mice

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2012, 22(1), pp.1-10
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

Chung Won Suk 1 Kim Sung-Soo 1 oh jaekeun 2 LEE JUN HWAN ORD ID 1 Kim Koh-Woon 1 박현건 1 최효정 1 Jongsoo Lee 1

1경희대학교
2한국체육대학교

Accredited

ABSTRACT

Objectives :The aim of this study was to investigate the acute toxicity and safety of fermented deer velvet antler extract in institute for cancer research(ICR) mice. Methods : To evaluate the acute toxicity and safety, fermented deer antler at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg were given orally to 25 male ICR mice for 14 days and allocated 5 mice for each group. After a single administration of fermented deer antler extract, we observed survival rates, general toxicity and any changes in body weight. Autopsies were conducted on all 25 mice. Results : Compared with the control group, we did not find any toxic alterations in any of the treated groups. Conclusions : A single dose of 5000 mg/kg of fermented deer antler extract was found to be safe in ICR mice. However, anything beyond this level has the potential to be lethal.

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