Anti-fatigue Effect of Fermented Deer Velvet Antler Extract in Sprague-Dawley Rats

Chung Won Suk (정원석); Kim Sung-Soo (김성수); oh jaekeun (오재근); LEE JUN HWAN (이준환); Kim Koh-Woon (김고운); 조융기; 연창호; Jongsoo Lee (이종수)

Anti-fatigue Effect of Fermented Deer Velvet Antler Extract in Sprague-Dawley Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2012, 22(1), pp.11-22
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

Chung Won Suk ¹, Kim Sung-Soo ¹, oh jaekeun ², LEE JUN HWAN ¹, Kim Koh-Woon ¹, 조융기 ¹, 연창호 ¹, Jongsoo Lee ¹

¹경희대학교
²한국체육대학교

Accredited

ABSTRACT

Objectives :The aim of this study was to investigate the Anti-muscle fatigue effect of fermented deer velvet antler extract in Sprague-Dawley rats. Methods : Rats were randomly divided into four groups of 10 mice each according to a randomized block design. Saline solution was orally administered to the control group, 100 mg/kg of water-extract of deer velvet antler to the positive control group, 50 mg/kg of fermented deer velvet antler extract to experimental group 1 and 100 mg/kg of fermented deer velvet antler extract to experimental group 2. Each of the four groups were treated for seven days and then participated in a forced swimming test which applied both a high intensity exercise model and a prolonged exercise model. We observed swimming times and examined blood biochemical parameters. Results : In the high intensity exercise model, the effect of the deer velvet antler was seen in the increased swimming times. Experimental group 2 swam for approximately 600% longer as compared to the control group(p<0.001), indicating that the recovery effect is dose-dependent. In the forced swimming tests using the prolonged exercise model, blood sugar levels(p<0.001) and free fatty acid levels(p<0.05, p<0.01 each) in the positive control group and experimental groups 1 and 2 demonstrated a significant recovery effect in comparison with the control group. Conclusions : Fermented deer velvet antler extract may have an Anti-muscle fatigue effect similar to that of deer velvet antler extract and could be used when it has an effect equal to one-fifth of the amount considering the yield rate.

KEYWORDS

Deer Antler, Fermentation, Anti-muscle fatigue effect, Oriental medicine

Citation status

* References for papers published after 2023 are currently being built.

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