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Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2012, 22(3), pp.49-63
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

기영범 1 김대훈 2 강대희 1 Kim Seon Jong 2 choi jin bong 2

1동신대학교 한의과대학 한방재활의학과
2동신대학교

Accredited

ABSTRACT

Objectives :This study was designed to evaluate the effects of Yukmijihwang-tang(Liuweidihuang-tang) and Cervi Pantotrichum Cornu pharmacopuncture on fracture healing in diabetic rats. Methods :In this study, 80 Sprague-Dawley rats were induced by STZ(streptozotocin) which was in general use as diabetes model. After the subjects were induced femur fracture, we divided the subjects into 4 groups : Control group with no treatment, experimental Ⅰ taken with Yukmijihwang-tang(Liuweidihuang-tang), experimental Ⅱ taken with Cervi Pantotrichum Cornu pharmacopuncture and experimental Ⅲ taken with Yukmijihwang-tang(Liuweidihuang-tang) and Cervi Pantotrichum Cornu pharmacopuncture groups. Serum T-ALP(total alkaline phosphatase), histological observation of callus formation, and the degree of TGF-β1(transforming growth factor beta 1) in each group were observed at the 7th, 14th, 21th day and at the 28th day respectively. Results :1. Experimental group Ⅰ and experimental group Ⅲ showed significant changes in serum T-ALP after 7-days of experimental period. All the experimental groups showed significant changes in serum T-ALP after 14-days of experimental period, especially experimental group Ⅲ showed more significant changes than other groups. 2. After 14-days, 21-days and 28-days, all the experimental groups showed significant changes in histological observation of callus formation, compared with control group. Especially experimental group Ⅲ showed more significant changes than other groups. 3. All the experimental groups showed significant changes in TGF-β1 compared with control group. Especially experimental group Ⅲ showed more significant changes than other groups. 4. Injury of liver tissue and kidney tissue in histological findings were not seen after 28-days of experimental period. Conclusions :It is suggested that Yukmijihwang-tang(Liuweidihuang-tang) and Cervi Pantotrichum Cornu pharmacopuncture may play a significant role in fracture healing in diabetic rats, and these two treatments could be more effective when used together.

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