@article{ART001683420},
author={기영범 and 김대훈 and 강대희 and Kim Seon Jong and choi jin bong},
title={Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2012},
volume={22},
number={3},
pages={49-63}
TY - JOUR
AU - 기영범
AU - 김대훈
AU - 강대희
AU - Kim Seon Jong
AU - choi jin bong
TI - Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2012
VL - 22
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 49
EP - 63
SN - 1229-1854
AB - Objectives :This study was designed to evaluate the effects of Yukmijihwang-tang(Liuweidihuang-tang) and Cervi Pantotrichum Cornu pharmacopuncture on fracture healing in diabetic rats.
Methods :In this study, 80 Sprague-Dawley rats were induced by STZ(streptozotocin) which was in general use as diabetes model. After the subjects were induced femur fracture, we divided the subjects into 4 groups : Control group with no treatment, experimental Ⅰ taken with Yukmijihwang-tang(Liuweidihuang-tang), experimental Ⅱ taken with Cervi Pantotrichum Cornu pharmacopuncture and experimental Ⅲ taken with Yukmijihwang-tang(Liuweidihuang-tang) and Cervi Pantotrichum Cornu pharmacopuncture groups. Serum T-ALP(total alkaline phosphatase), histological observation of callus formation, and the degree of TGF-β1(transforming growth factor beta 1) in each group were observed at the 7th, 14th, 21th day and at the 28th day respectively.
Results :1. Experimental group Ⅰ and experimental group Ⅲ showed significant changes in serum T-ALP after 7-days of experimental period. All the experimental groups showed significant changes in serum T-ALP after 14-days of experimental period, especially experimental group Ⅲ showed more significant changes than other groups.
2. After 14-days, 21-days and 28-days, all the experimental groups showed significant changes in histological observation of callus formation, compared with control group. Especially experimental group Ⅲ showed more significant changes than other groups.
3. All the experimental groups showed significant changes in TGF-β1 compared with control group. Especially experimental group Ⅲ showed more significant changes than other groups.
4. Injury of liver tissue and kidney tissue in histological findings were not seen after 28-days of experimental period.
Conclusions :It is suggested that Yukmijihwang-tang(Liuweidihuang-tang) and Cervi Pantotrichum Cornu pharmacopuncture may play a significant role in fracture healing in diabetic rats, and these two treatments could be more effective when used together.
KW - Yukmijihwang-tang(Liuweidihuang-tang);Cervi Pantotrichum Cornu pharmacopuncture;Fracture;Diabetic rats
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기영범, 김대훈, 강대희, Kim Seon Jong and choi jin bong. (2012). Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats. Journal of Korean Medicine Rehabilitation, 22(3), 49-63.
기영범, 김대훈, 강대희, Kim Seon Jong and choi jin bong. 2012, "Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats", Journal of Korean Medicine Rehabilitation, vol.22, no.3 pp.49-63.
기영범, 김대훈, 강대희, Kim Seon Jong, choi jin bong "Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats" Journal of Korean Medicine Rehabilitation 22.3 pp.49-63 (2012) : 49.
기영범, 김대훈, 강대희, Kim Seon Jong, choi jin bong. Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats. 2012; 22(3), 49-63.
기영범, 김대훈, 강대희, Kim Seon Jong and choi jin bong. "Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats" Journal of Korean Medicine Rehabilitation 22, no.3 (2012) : 49-63.
기영범; 김대훈; 강대희; Kim Seon Jong; choi jin bong. Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats. Journal of Korean Medicine Rehabilitation, 22(3), 49-63.
기영범; 김대훈; 강대희; Kim Seon Jong; choi jin bong. Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats. Journal of Korean Medicine Rehabilitation. 2012; 22(3) 49-63.
기영범, 김대훈, 강대희, Kim Seon Jong, choi jin bong. Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats. 2012; 22(3), 49-63.
기영범, 김대훈, 강대희, Kim Seon Jong and choi jin bong. "Effects of Yukmijihwang-tang(Liuweidihuang-tang ) and Cervi Pantotrichum Cornu Pharmacopuncture on Fracture Healing in Diabetic Rats" Journal of Korean Medicine Rehabilitation 22, no.3 (2012) : 49-63.