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@article{ART001683421},
author={전규상 and 김일현 and 임광묵 and SONG YUNG SUN},
title={Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2012},
volume={22},
number={3},
pages={65-78}

TY - JOUR
AU - 전규상
AU - 김일현
AU - 임광묵
AU - SONG YUNG SUN
TI - Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells
JO - Journal of Korean Medicine Rehabilitation
PY - 2012
VL - 22
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 65
EP - 78
SN - 1229-1854
AB - Objectives :Sodok-eum(xiāodú-yˇln, SDU) exhibits potent anti-inflammatory activity with an unknown mechanism. The purpose of this study is to elucidate the molecular mechanisms of SDU on pharmacological and biochemical actions in inflammation. Methods :We examined the effect of SDU on pro-inflammatory mediators in lipopolysaccharide(UVB)-stimulated HaCaT. The investigation focused on whether SDU inhibited cyclooxygenase-2(COX-2), interleukin-6(IL-6), interleukin-8(IL-8) and mitogen-activated protein kinases(MAPKs) in UVB-stimulated HaCaT cells. Results :SDU inhibited UVB-induced IL-6, IL-8 productions as well as the expressions of COX-2. Furthermore, SDU suppressed the UVB-induced phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2), c-JUN N-terminal kinase 1/2(JNK 1/2), p38. Conclusions :These results suggest that SDU has inhibitory effects on UVB-induced IL-6, IL-8 production, as well as the expressions of COX-2 in the HaCaT. The inhibitory effects occur through blockades on the phosphorylation of MAPKs following activation.
KW - Sodok-eum(xiāodú-yˇln);UVB;HaCaT;COX-2;IL-6;IL-8;MAPKs
DO -
UR -
ER -

전규상, 김일현, 임광묵 and SONG YUNG SUN. (2012). Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells. Journal of Korean Medicine Rehabilitation, 22(3), 65-78.

전규상, 김일현, 임광묵 and SONG YUNG SUN. 2012, "Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells", Journal of Korean Medicine Rehabilitation, vol.22, no.3 pp.65-78.

전규상, 김일현, 임광묵, SONG YUNG SUN "Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells" Journal of Korean Medicine Rehabilitation 22.3 pp.65-78 (2012) : 65.

전규상, 김일현, 임광묵, SONG YUNG SUN. Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells. 2012; 22(3), 65-78.

전규상, 김일현, 임광묵 and SONG YUNG SUN. "Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells" Journal of Korean Medicine Rehabilitation 22, no.3 (2012) : 65-78.

전규상; 김일현; 임광묵; SONG YUNG SUN. Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells. Journal of Korean Medicine Rehabilitation, 22(3), 65-78.

전규상; 김일현; 임광묵; SONG YUNG SUN. Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells. Journal of Korean Medicine Rehabilitation. 2012; 22(3) 65-78.

전규상, 김일현, 임광묵, SONG YUNG SUN. Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells. 2012; 22(3), 65-78.

전규상, 김일현, 임광묵 and SONG YUNG SUN. "Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells" Journal of Korean Medicine Rehabilitation 22, no.3 (2012) : 65-78.