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Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2012, 22(3), pp.65-78
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

전규상 1 김일현 1 임광묵 2 SONG YUNG SUN 3

1원광대학교 한의학대학 한방재활의학과교실
2우석대학교 한의과대학 한방재활의학과
3원광대학교

Accredited

ABSTRACT

Objectives :Sodok-eum(xiāodú-yˇln, SDU) exhibits potent anti-inflammatory activity with an unknown mechanism. The purpose of this study is to elucidate the molecular mechanisms of SDU on pharmacological and biochemical actions in inflammation. Methods :We examined the effect of SDU on pro-inflammatory mediators in lipopolysaccharide(UVB)-stimulated HaCaT. The investigation focused on whether SDU inhibited cyclooxygenase-2(COX-2), interleukin-6(IL-6), interleukin-8(IL-8) and mitogen-activated protein kinases(MAPKs) in UVB-stimulated HaCaT cells. Results :SDU inhibited UVB-induced IL-6, IL-8 productions as well as the expressions of COX-2. Furthermore, SDU suppressed the UVB-induced phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2), c-JUN N-terminal kinase 1/2(JNK 1/2), p38. Conclusions :These results suggest that SDU has inhibitory effects on UVB-induced IL-6, IL-8 production, as well as the expressions of COX-2 in the HaCaT. The inhibitory effects occur through blockades on the phosphorylation of MAPKs following activation.

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