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@article{ART001765705},
author={정벌 and Jongsoo Lee},
title={Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2013},
volume={23},
number={2},
pages={1-15}

TY - JOUR
AU - 정벌
AU - Jongsoo Lee
TI - Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents
JO - Journal of Korean Medicine Rehabilitation
PY - 2013
VL - 23
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 1
EP - 15
SN - 1229-1854
AB - Objectives :In present study, we investigated the effects of ginsenoside Rg3 on early-stage inflammatory response in spinal cord compression of rodents. Methods :Spinal cord injury(SCI) was induced by a vascular clip method(30 g, 5 min) on the spinal cord of mice. Rg3 was treated orally at 1 hour prior to the SCI induction. Messenger ribonucleic acid(mRNA) expression of tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), interleukin-6(IL-6) and cyclooxygenase-2(COX-2) was measured by the real-time polymerase chain reaction(RT-PCR). Microglia in the spinal cord tissue, neurophils and COX-2 in the peri-lesion and inducible nitric oxide synthase(iNOS) expression in the ventral horn of SCI induced rats were measured by immunohistochemical stain. Results :1. Rg3 significantly reduced the mRNA expression of TNF-α, IL-1β, and COX-2 in the spinal cord tissue compared with SCI group(p<0.05, p<0.01). 2. Rg3 significantly reduced the total number of activated microglia and proportion of phagocytic form in the total activated microglia compared with SCI group(p<0.05, p<0.01). 3. Rg3 significantly reduced myeloperoxidase(MPO) positive neurophil in the peri-lesion compared with SCI group(p<0.05). 4. Rg3 reduced the COX-2 expression in the tissue and motor neurons compared with SCI group. 5. Rg3 significantly reduced iNOS positive motor neurons in the ventral horn compared with SCI group(p<0.01). Conclusions :In conclusion, we demonstrated at first that treatment of ginsenoside Rg3 could reduce significantly the levels of inflammatory mediators in a spinal cord compression model of rodents. Therefore, these results suggested that ginsenoside Rg3 may be a useful antimiflamatory therapeutic candidate for SCI.
KW - Ginsenoside Rg3;Early-stage inflammatory response;Spinal cord injury
DO -
UR -
ER -

정벌 and Jongsoo Lee. (2013). Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents. Journal of Korean Medicine Rehabilitation, 23(2), 1-15.

정벌 and Jongsoo Lee. 2013, "Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents", Journal of Korean Medicine Rehabilitation, vol.23, no.2 pp.1-15.

정벌, Jongsoo Lee "Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents" Journal of Korean Medicine Rehabilitation 23.2 pp.1-15 (2013) : 1.

정벌, Jongsoo Lee. Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents. 2013; 23(2), 1-15.

정벌 and Jongsoo Lee. "Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents" Journal of Korean Medicine Rehabilitation 23, no.2 (2013) : 1-15.

정벌; Jongsoo Lee. Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents. Journal of Korean Medicine Rehabilitation, 23(2), 1-15.

정벌; Jongsoo Lee. Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents. Journal of Korean Medicine Rehabilitation. 2013; 23(2) 1-15.

정벌, Jongsoo Lee. Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents. 2013; 23(2), 1-15.

정벌 and Jongsoo Lee. "Effects of Ginsenoside Rg3 on Early-stage Inflammatory Response in Spinal Cord Compression of Rodents" Journal of Korean Medicine Rehabilitation 23, no.2 (2013) : 1-15.