Effect of Bee Venom Pharmacopuncture and Scolopendra Subspinipes Pharmacopuncture on Functional Recovery and Anti-inflammation after Sciatic Crushed Nerve Injury in Rats (봉독약침과 오공약침이 좌골신경 손상 흰쥐의 기능 회복과 염증 억제에 미치는 영향)

이길재; SONG YUN KYUNG (송윤경); Lim Hyung Ho (임형호)

Effect of Bee Venom Pharmacopuncture and Scolopendra Subspinipes Pharmacopuncture on Functional Recovery and Anti-inflammation after Sciatic Crushed Nerve Injury in Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2013, 23(2), pp.17-31
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

이길재 ¹, SONG YUN KYUNG ², Lim Hyung Ho ²

¹가천대학교 한의과대학 한방재활의학과교실
²가천대학교

Accredited

ABSTRACT

Objectives :Peripheral nerve injuries are commonly encountered clinical problems and often result in serve functional deficit. Bee venom and scolopendra subspinipes have been traditionally used in oriental medicine to treat several inflammatory diseases and chronic pain conditions. Methods :In the present study, the effects of bee venom pharmacopuncture and scolopendra subspinipes pharmacopuncture on functional recovery, severity of pain, and expressions of neurofilament, cycloxygenease-2(COX-2), and tumor necrosis factor-α(TNF-α) following sciatic crushed nerve injury in rats were investigated. For this study, walking tract analysis, plantar test, western blot for COX-2 and TNF-α, and immunohistochemistry for neurofilament were performed. Results :In the present results, sciatic functional index(SFI) in walking tract analysis was significantly decreased following sciatic crushed nerve injury, and pain severity in plantar test was significantly increased. COX-2 and TNF-α expressions were increased whereas neurofilament expression was decreased by sciatic crushed nerve injury. On the other hand, bee venom pharmacopuncture and scolopendra subspinipes pharmacopuncture improved SFI in walking tract analysis and suppressed the pain severity in sciatic crushed nerve injury. Bee venom pharmacopuncture and scolopendra subspinipes pharmacopuncture suppressed COX-2 and TNF-α expression and enhanced the neurofilament expression in sciatic crushed nerve injury. Conclusions :In the present study, we have shown that treatment with bee venom or scolopendra subspinipes is the effective therapeutic modality to ameliorate the symptoms of sciatic crushed nerve injury. The efficacies of bee venom and scolopendra subspinipes were similar.

KEYWORDS

Sciatic nerve injury, Bee venom Pharmacopuncture, Scolopendra subspinipes Pharmacopuncture

Citation status

* References for papers published after 2023 are currently being built.

[journal] 김상범 / 1993 / 외상성 말초신경 손상에 대한 임상적 고찰 / 동국의학 1 : 43~50

[journal] Kline DG / 1998 / Management and results of sciatic nerve injuries a 24-year experience / J Neurosurg 89 : 13~23

[journal] Cornwall R / 2000 / Nerve injury in traumatic dislocation of the hip / Clin Orthop 377 : 84~91

[journal] 현정근 / 2004 / The Eletrodiagnostic Findings of Sciatic Nerve Injury according to the Locations and Etiologies / Annals of Rehabilitation Medicine / 대한재활의학회 28(1) : 54~58

[journal] Leung L / 2010 / TNF-alpha and neuropathic pain-a review / J Neuroinflammation 16 : 7~27

[journal] Baron R. / 2000 / The long path from mechanisms to mechanism-based treatment / Der Anaesthesist 49 : 373~386

[journal] 이동현 / 2005 / Effects of Bee Venom Acupuncture Injected at Hwando(GB30) on Neuropathic Pain in Rats / 대한침구의학회지 / 대한침구의학회 22(5) : 67~77

[journal] 김성남 / 2004 / Inhibitory Effect of Scolopendrid Aqua-Acupuncture Injected at Hwando(GB30) on Neuropathic Pain in Rats / 대한침구의학회지 / 대한침구의학회 21(3) : 145~168

[journal] 김선종 / 2007 / Analgesic Effects of Herba Chelidonii Pharmacopuncture in the Rat Models of Peripheral Neuropathic Pain / 한방재활의학과학회지 / 한방재활의학과학회 17(2) : 1~16

[journal] 김지영 / 1997 / 蜂毒療法의 最新硏究動向에 對한 考察 / 대한침구학회지 14 : 47~71

[journal] 이상훈 / 2003 / Effects of Bee Venom on the pain, edema, and acute inflammatory reactant of Rheumatoid Arthritis patients / 대한침구의학회지 / 대한침구의학회 20(2) : 7~84

[journal] 왕오호 / 2001 / 退行性膝關節炎의 蜂毒藥鍼治療效果에 대한 臨床的觀察 / 대한침구학회지 18 : 35~47

[journal] 권기록 / 2001 / Three cases of affections of the hip treated with Korean Bee-Venom therapy / Journal of Pharmacopuncture / 대한약침학회 4(3) : 127~134

[journal] 권기록 / 2000 / 봉약침요법의 면역반응에 관한 임상적 연구 / 대한침구학회지 17 : 169~174

[journal] 정경숙 / 2005 / Clinical Study on the Effect of Bee Venom Acupuncture Therapy on the Post-stroke Pain / 대한침구의학회지 / 대한침구의학회 22(3) : 69~76

[book] 대한약침학회 / 1997 / 약침제재와 임상응용(Ⅰ) / 대한약침학회 출판부 : 227~

[journal] 송춘호 / 1997 / 蜈蚣水鍼이 鎭痛 및 鎭痙效果에 미치는 影響 / 대한침구 학회지 14 : 219~230

[journal] 이삼로 / 2004 / Effects of Scolopendrid Water-Alcohol Extract Injection Applied to the Acupuncture Point on the Neuropathic Pain in Rats / Korean Journal of Acupuncture / 경락경혈학회 21(2) : 47~68

[journal] 이동희 / 1997 / 蜈蚣의 항고혈압작용에 관한 연구 / 대한본초학회지 : 1239~1249

[journal] 김길섭 / 1998 / 蜈蚣이 老齡에 따른 mouse의 免疫機能\에 미치는 影響 / 대한한방 내과학회지 19 : 477~487

[journal] 최용건 / 2008 / Antioxidative Effects of Scolopendra subspinipes / 동의신경정신과학회지 / 대한한방신경정신과학회 19(3) : 129~142

[book] 고형균 / 2003 / 동의수의침구학 / 경희대학교출판국 : 34~40

[journal] Bain JR / 1989 / Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat / Plast Reconstr Surg 83 : 129~138

[journal] Pavić R / 2011 / Rat sciatic nerve crush injury and recovery tracked by plantar test and immunohistochemistry analysis / Coll Antropol 35 : 93~100

[journal] Kemp SW / 2008 / Growth factor and stem cell enhanced conduits in peripheral nerve regeneration and repair / Neurol Res 30 : 1030~1038

[journal] Delmotte A / 2009 / Physiology of the injured peripheral nerve / Neurochirurgie 1 : 13~21

[journal] Irintchev A / 2011 / Potentials and limitations of peripheral nerve injury models in rodents with particular reference to the femoral nerve / Ann Anat 193 : 276~285

[journal] Klusáková I / 2009 / Experimental models of peripheral neuropathic pain based on traumatic nerve injuries-an anatomical perspective / Ann Anat 191 : 248~259

[book] 대한약침학회 학술위원회 / 2008 / 약침학 / 엘스비아코리아(유) : 6~30

[journal] Ameratunga RV / 1995 / A high efficiency method for purification and assay of bee venom phospholipase A2 / Pathology 27 : 157~160

[journal] Rybak-Chmielewska H / 2004 / HPLC study of chemical composition of honeybee venom / J Agric Sci 48 : 103~109

[journal] Kokot ZJ / 2009 / Simultaneous determination of major constituents of honeybee venom by LC-DAD / Chromatographia 69 : 1~5

[journal] Kwon YB / 2002 / The water soluble fraction of bee venom produces antinociceptive and antiinflammatory effects on rheumatoid arthritis in rats / Life Sci 71 : 191~204

[journal] 안중철 / 2006 / Experimental Study on the comparison of antibacterial and antioxidant effects between the Bee Venom and Sweet Bee Venom / Journal of Pharmacopuncture / 대한약침학회 9(3) : 97~104

[journal] Tu WC / 2008 / Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells / Toxicon 52 : 318~329

[journal] 정혜윤 / 2002 / The effects of Honey Bee Venom for Aqua-acupuncture on Expression of Genes Related with Inflammation and Pain / 대한침구의학회지 / 대한침구의학회 19(3) : 41~50

[journal] 한상미 / 2005 / 국내산봉독에 의한 BV-2 세포주에서 Nitric Oxide와 Tumor Necrocis Factor-α 생성에 미치는항신경염증 작용에 관한 연구 / 한국양봉학회지 20 : 95~102

[journal] 조일주 / 2011 / Anti-Inflammatory Effect of Aqueous Extract of Scolopendrae Corpus in RAW 264.7 Cells / 대한본초학회지 / 대한본초학회 26(3) : 23~29

[book] 김창민 / 1998 / 중약대사전 / 정담 : 3912~3923

[book] 전국한의과대학 본초학 교수 / 2000 / 본초학 / 영림사 : 508~509

[journal] 고강훈 / 2001 / Clinical study on treatment of HIVD of lumbar spine using Scolopendrid herbal acupuncture / Journal of Pharmacopuncture / 대한약침학회 4(3) : 47~57

[journal] 김성남 / 2004 / Clinical Study on Effect of Scolopendrid Aquacupuncture Classified by the Type of Lumbar Disc Herniation. / 대한침구의학회지 / 대한침구의학회 21(5) : 79~100

[book] 전국한의과대학 침구경혈학교실 / 1998 / 침구학(상) / 집문당 : 643~645

[book] 나영분 / 1998 / 수혈학 / 상해과학기술출판사 : 186~187

[journal] Dellon AL / 1989 / Sciatic nerve regeneration in the rat. Validity of walking track assessment in the presence of chronic contractures / Microsurgery 10 : 220~225

[journal] Fawcett JW / 1990 / Peripheral nerve regeneration / Annu Rev Neurosci 13 : 43~60

[book] Fawcett JW / 2001 / Peripheral nerve regeneration in Brain damage, Brain repair / Oxford University Press : 145~154

[journal] Akassoglou K / 2002 / Fibrin inhibits peripheral nerve regeneration by arresting Schwann cell differentiation / Neuron 33 : 861~875

[journal] 은영준 / 2011 / Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats / 한방재활의학과학회지 / 한방재활의학과학회 21(2) : 125~142

[journal] Schwager J / 1998 / Modulation of interleukin production by ascorbic acid / Vet Immunol Immunopathol 64 : 45~57

[journal] Durrenberger PF / 2004 / Cyclooxygenase-2 in injured human nerve and a rat model of nerve injury / J Peripher Nerv Syst 9 : 15~25

[journal] Schäfers M / 2004 / Cyclooxygenase inhibition in nerve-injury-and TNF-induced hyperalgesia in the rat / Exp Neurol 185 : 160~168

KJCKorea
Journal Central

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6