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Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2013, 23(4), pp.9-21
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

허성규 1 박원형 1 Cha Yun Yeop 1

1상지대학교

Accredited

ABSTRACT

Objectives The purpose of this study was investigating effects of Jengjengamiyijin-tang(zhèngzhuànjiāwèièrchéntāng) (JGYT) on lowering lipid, antioxidation and production of inflammatorymediators being used rats fed on high oxidized fat. Methods We divided fat Sprague-Dawley rats fed on high oxidized into 4 groups. Eachof 8 rats was divided into a control group and experimental groups. We fed a control groupof rats a basal diet and administered normal saline (100 mg/kg, 1 time/1 day) for 4 weeks. And We fed each experimental group of rats basal diet and administered an extract ofJGYT extracts (100 mg/kg, 200 mg/kg, 300 mg/kg, 1 time/1 day) for 4 weeks. At the endof the experiment, the rats were sacrificed to determine their chemical composition. Wemeasured lipid of plasma and liver, concentration of proinflammatory cytokines, antioxidativeactivity and plasma tumor necrosis factor-α (TNF-α), plasma interleukin-6 (IL-6),Apo-B, Apo-E and Leptin gene expression. Results 1. Concentration of plasma FFA, LDL-cholesterol, plasma and liver total cholesterolshowed a significant decrement in JGYT groups. However, concentration of plasmaHDL-cholesterol showed a significant increment in JGYT groups. 2. Concentration of plasmaand liver TG, TBARS showed a significant decrement in JGYT groups. However, concentrationof liver GSH-Px, SOD and CAT showed a significant increment in JGYT groups. 3. Plasma GPT activity and concentration of plasma IL-6, TNF-α, NO, Ceruloplasmin, α1-acid glycoprotein showed a significant decrement in JGYT groups. 4. In the analysis ofRT-PCR, gene expression of Apo-B and Apo-E in the JGYT groups showed a low expressionthan that of control group. However, the gene expression of leptin showed no differencein all the treatment groups. 5. The ratio of leptin expression per β-actin expressionshowed no significant difference among all treatment groups. However, The ratio of Apo-Band Apo-E expression per β-actin expression showed a significant decrement in JGYTgroups. Conclusions According to this study, extract of JGYT showed a positive effect in loweringlipid, antioxidation and control of inflammatory mediators production.

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