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Journal Central

@article{ART001813603},
author={허성규 and 박원형 and Cha Yun Yeop},
title={Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2013},
volume={23},
number={4},
pages={9-21}

TY - JOUR
AU - 허성규
AU - 박원형
AU - Cha Yun Yeop
TI - Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat
JO - Journal of Korean Medicine Rehabilitation
PY - 2013
VL - 23
IS - 4
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 9
EP - 21
SN - 1229-1854
AB - Objectives The purpose of this study was investigating effects of Jengjengamiyijin-tang(zhèngzhuànjiāwèièrchéntāng) (JGYT) on lowering lipid, antioxidation and production of inflammatorymediators being used rats fed on high oxidized fat. Methods We divided fat Sprague-Dawley rats fed on high oxidized into 4 groups. Eachof 8 rats was divided into a control group and experimental groups. We fed a control groupof rats a basal diet and administered normal saline (100 mg/kg, 1 time/1 day) for 4 weeks. And We fed each experimental group of rats basal diet and administered an extract ofJGYT extracts (100 mg/kg, 200 mg/kg, 300 mg/kg, 1 time/1 day) for 4 weeks. At the endof the experiment, the rats were sacrificed to determine their chemical composition. Wemeasured lipid of plasma and liver, concentration of proinflammatory cytokines, antioxidativeactivity and plasma tumor necrosis factor-α (TNF-α), plasma interleukin-6 (IL-6),Apo-B, Apo-E and Leptin gene expression. Results 1. Concentration of plasma FFA, LDL-cholesterol, plasma and liver total cholesterolshowed a significant decrement in JGYT groups. However, concentration of plasmaHDL-cholesterol showed a significant increment in JGYT groups. 2. Concentration of plasmaand liver TG, TBARS showed a significant decrement in JGYT groups. However, concentrationof liver GSH-Px, SOD and CAT showed a significant increment in JGYT groups. 3. Plasma GPT activity and concentration of plasma IL-6, TNF-α, NO, Ceruloplasmin, α1-acid glycoprotein showed a significant decrement in JGYT groups. 4. In the analysis ofRT-PCR, gene expression of Apo-B and Apo-E in the JGYT groups showed a low expressionthan that of control group. However, the gene expression of leptin showed no differencein all the treatment groups. 5. The ratio of leptin expression per β-actin expressionshowed no significant difference among all treatment groups. However, The ratio of Apo-Band Apo-E expression per β-actin expression showed a significant decrement in JGYTgroups. Conclusions According to this study, extract of JGYT showed a positive effect in loweringlipid, antioxidation and control of inflammatory mediators production.
KW - Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng);Lowering lipid;Anti-oxidation;Inflammatory mediator
DO -
UR -
ER -

허성규, 박원형 and Cha Yun Yeop. (2013). Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat. Journal of Korean Medicine Rehabilitation, 23(4), 9-21.

허성규, 박원형 and Cha Yun Yeop. 2013, "Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat", Journal of Korean Medicine Rehabilitation, vol.23, no.4 pp.9-21.

허성규, 박원형, Cha Yun Yeop "Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat" Journal of Korean Medicine Rehabilitation 23.4 pp.9-21 (2013) : 9.

허성규, 박원형, Cha Yun Yeop. Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat. 2013; 23(4), 9-21.

허성규, 박원형 and Cha Yun Yeop. "Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat" Journal of Korean Medicine Rehabilitation 23, no.4 (2013) : 9-21.

허성규; 박원형; Cha Yun Yeop. Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat. Journal of Korean Medicine Rehabilitation, 23(4), 9-21.

허성규; 박원형; Cha Yun Yeop. Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat. Journal of Korean Medicine Rehabilitation. 2013; 23(4) 9-21.

허성규, 박원형, Cha Yun Yeop. Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat. 2013; 23(4), 9-21.

허성규, 박원형 and Cha Yun Yeop. "Effects of Jengjengamiyijin-tang (zhèngzhuànjiāwèièrchéntāng) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat" Journal of Korean Medicine Rehabilitation 23, no.4 (2013) : 9-21.