Therapeutic Effects of Acupuncture and Herbal External Preparation on Healing of Deep Partial Thickness Burn Wound in Rats (심재성 2도 화상이 유발된 흰쥐의 조직 회복에 대한 침 및 한약외용제의 효과)

Jo Hee Geun (조희근); 박애련; choi jin bong (최진봉)

Therapeutic Effects of Acupuncture and Herbal External Preparation on Healing of Deep Partial Thickness Burn Wound in Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2014, 24(3), pp.87-98
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

Jo Hee Geun ¹, 박애련 ², choi jin bong ³

¹동신대학교 한의과대학 순창의료원
²동신대학교 한의과대학 한방재활의학과교실
³동신대학교

Accredited

ABSTRACT

Objectives The present study aimed to investigate the effects of acupuncture and herbal external preparation on wound healing procedure in a deep partial thickness burn model in rats. Methods A total of 40 male Sprague-Dawley rats were allocated into four groups with an equal number in each group: acupuncture treatment group, herbal external perparation group, Silver sulfadiazine dressing group and control group. We describe the effect of acupuncture and herbal external preparation on morphologic and histologic changes, epithelial growth factor (EGF), hematological value of the deep partial thickness burn wound in rats. Results At 21th day after wounding the wound size in acupuncture treat group and herbal external preparation group were decreased more significantly compared to control group. In addition, epidermal regeneration on acupuncture treatment was than other treatment and control group in histological finding. Hematological findings revealed that acupuncture treatment group and herbal external prepartion group was more effective than control group in reducing inflammation response induced by burn. In acupuncture treated group, neutrophil and leukocyte level were significantly decreased compared to other treatment group. Also, this study showed that EGF was obviously expressed in nascent tissue when wounds were treated with the acupuncture and herbal external preparation after injury. In particular, acupuncture treatment group had a significant increase of EGF expression in burn wound healing area when compared with the other treatment groups. Conclusions These findings suggest that acupuncture and herbal external prepration may improve burn wound healing through decreasing inflammatory reaction, increasing tissue regeneration and expression of EGF. Moreover, acupuncture treatment could be more effective in comparison with Silver sulfadiazine dressing.

KEYWORDS

Deep partial thickness burn, EGF, Acupuncture, Herbal external preparation, Regeneration

Citation status

* References for papers published after 2023 are currently being built.

[journal] Kim DC / 2011 / Epidemiology of Burns in Korea / J Korean Burn Soc 14 : 6~11

[journal] Pauldine R / 2008 / Considerations in burn critical care / Contemp Crit Care 6(3) : 1~11

[journal] Roberts JR / 2003 / Minor burns : initial therapy / Emerg Med News 25(3) : 28~31

[journal] Singer AJ / 2008 / Current management of acute cutaneous wounds / N Engl J Med 359(10) : 1037~1046

[journal] Sheridan R / 2005 / Outpatient burn care in the emergency department / Pediatr Emerg Care 21(7) : 449~456

[journal] Atiyeh BS / 2007 / Effect of silver on burn wound infection control and healing : review of the literature / Burns 33(2) : 139~148

[journal] Fuller FW / 2009 / The side effects of silver sulfadiazine / J Burn Care Res 30(3) : 464~470

[journal] Wasiak J / 2013 / Dressings for superficial and partial thickness burns / Cochrane Database Syst Rev 3 : CD002106~

[journal] Kopp J / 2003 / Ancient traditional Chinese medicine in burn treatment : a historical review / Burns 29(5) : 473~478

[journal] Jewo PI / 2009 / A Comparative Study of the Wound Healing Properties of Moist Exposed Burn Ointment(MEBO)and Silver Sulphadiazine / Ann Burns Fire Disasters 22(2) : 79~82

[journal] Hirsch T / 2008 / Moist Exposed Burn Ointment(MEBO)in partial thickness burns-a randomized, comparative open mono-center study on the efficacy of dermaheal(MEBO)ointment on thermal 2nd degree burns compared to conventional therapy / Eur J Med Res 13(11) : 505~510

[journal] Jull AB / 2008 / Honey as a topical treatment for wounds / Cochrane Database Syst Rev (4) : CD005083~

[journal] Maenthaisong R / 2007 / The efficacy of aloe vera used for burn wound healing : a systematic review / Burns 33(6) : 713~718

[journal] Lee JA / 2011 / Acupuncture accelerates wound healing in burn-injured mice / Burns 37(1) : 117~125

[journal] 지규용 / 2002 / A Study on Histological Recuperative Effect of Burn Remedies / 동의생리병리학회지 / 대한동의병리학회 16(4) : 24~781

[journal] 김희경 / 2011 / The anti-inflammatory effects of Huang-Lyun (Coptidis Rhizoma, CR) on injured tissue after burn elicitation / 대한한의학회지 / 대한한의학회 32(2) : 1~13

[journal] 송범용 / 2009 / Effects of the Acupuncture or Pharmacopunture Treatment for the Histologic and Morphologic Recovery on the Mouse with the Burn Skin / 대한침구의학회지 / 대한침구의학회 26(3) : 81~92

[journal] Bradford M. M / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 248~254

[journal] Hoeksema H / 2013 / A comparative study of 1% silver sulphadiazine(FlammazineⓇ)versus an enzyme alginogel(FlaminalⓇ)in the treatment of partial thickness burns / Burns 39(6) : 1234~1241

[journal] Gupta SS / 2011 / Honey dressing versus silver sulfadiazene dressing for wound healing in burn patients : a retrospective study / J Cutan Aesthet Surg 4(3) : 183~187

[journal] Gurfinkel R / 2012 / Comparison of purified olive oil and silver sulfadiazine in the treatment of partial thickness porcine burns / Am J Emerg Med 30(1) : 79~83

[journal] Tiwari VK. / 2012 / Burn wound: How it differs from other wounds? / Indian J Plast Surg 45(2) : 364~373

[journal] Deitch EA / 1983 / Hypertrophic burn scars : analysis of variables / J Trauma 23(10) : 895~898

[journal] Buganza Tepole A / 2013 / Systems-based approaches toward wound healing / Pediatr Res 73(4 Pt 2) : 553~563

[journal] Wong VW1 / 2011 / Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling / Nat Med 18(1) : 148~152

[journal] Park SI / 2012 / Therapeutic Effects of Acupuncture through Enhancement of Functional Angiogenesis and Granulogenesis in Rat Wound Healing / Evid Based Complement Alternat Med 2012 : 464586~

[journal] de Almeida Mdos S / 2012 / Electroacupuncture increases the concentration and organization of collagen in a tendon healing model in rats / Connect Tissue Res 53(6) : 542~547

[journal] Saarto EE / 2010 / Effect of a single acupuncture treatment on surgical wound healing in dogs : a randomized, single blinded, controlled pilot study / Acta Vet Scand 52 : 57~

[journal] Martin P / 2005 / Inflammatory cells during wound repair : the good, the bad and the ugly / Trends Cell Biol 15(11) : 599~607

[journal] Yan XK / 2013 / Decreasing effect of electro-acupuncture at Sanyin points on inflammatory cytokines in autoimmune prostatitis rats / Zhonghua Nan Ke Xue 19(5) : 451~455

[journal] Xu YD / 2012 / Proteomic analysis reveals the deregulation of inflammation-related proteins in acupuncture-treated rats with asthma onset / Evid Based Complement Alternat Med 2012 : 850512~

[journal] Muluye RA / 2014 / Anti-inflammatory and Antimicrobial Effects of Heat-Clearing Chinese Herbs : A Current Review / J Tradit Complement Med 4(2) : 93~98

[journal] Mimura Y / 2006 / Epidermal growth factor affects the synthesis and degradation of type I collagen in cultured human dermal fibroblasts / Matrix Biol 25(4) : 202~212

[journal] Coşkun S / 2007 / Effects of epidermal growth factor on lipid peroxidation and nitric oxide levels in oral mucosal ulcer healing : a time-course study / Surg Today 37(7) : 570~574

[journal] Barrientos S / 2008 / Growth factors and cytokines in wound healing / Wound Repair Regen 16(5) : 585~601

[journal] Fernández-Montequín JI1 / 2009 / Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers : multicenter, randomised, placebo-controlled, double-blind study / Int Wound J 6(6) : 432~443

[journal] Yan J / 2005 / Effect of acupuncture at different meridian acupoints on changes of related factors for rabbit gastric mucosal injury / World J Gastroenterol 11(41) : 6472~6476

[journal] Ji LX / 2008 / Effects of electroacupuncture at points"Weibingfang"on EGF and EGFR mRNA expressions in rats with lesion of gastric mucosa / Zhongguo Zhen Jiu 28(10) : 757~759

[journal] Wu MH / 2007 / Study of qingre liyan decoction in treating and preventing acute radioactive oral mucositis / Chin J Integr Med 13(4) : 280~284

[journal] Bairy KL / 1997 / An experimental model to produce partial thickness burn wound / Indian J Exp Biol 35(1) : 70~72

KJCKorea
Journal Central

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6