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@article{ART002076593},
author={이하일 and 이종하 and 권영미 and SONG YUNG SUN},
title={Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2016},
volume={26},
number={1},
pages={13-31}

TY - JOUR
AU - 이하일
AU - 이종하
AU - 권영미
AU - SONG YUNG SUN
TI - Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice
JO - Journal of Korean Medicine Rehabilitation
PY - 2016
VL - 26
IS - 1
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 13
EP - 31
SN - 1229-1854
AB - ObjectivesIn this study, it was investigated whether Gami-Handayeolso-Tang (HDYST) medication has anti-obesity effects in high fat diet (HFD)-fed obese mice.MethodsThe experimental animals were divided into five groups—normal diet-fed (ND), high fat diet-fed control (HFD), HFD＋HDYST 150, HFD＋HDYST 300, and HFD＋orlistat as a positive drug. The obese markers such as body weight, diet efficiency ratio, serum lev-els of total cholesterol, triglyceride, lipid contents, leptin, adiponectin, and GOT/GPT were measured. Also, white adipose tissue, liver weight, abdominal fat mass, hepatic lipid con-tents, and mRNA expression of obese-associating genes were examined in obese mice.ResultsIn high fat diet-fed mice, HDYST administration significantly decreased body weight, diet efficiency ratio, serum levels of total cholesterol, triglyceride, LDL-cholesterol, as well as leptin and GOT/GPT, compared to the HFD group in a dose-dependent manner. HDYST increased significantly the serum levels of HDL-cholesterol and adiponectin. It also reduced the accumulation of lipids, such as total lipid and triglycerides, in organs such as liver and abdominal adipose tissue. Moreover, HDYST administration significantly de-creased the expression levels of fatty acid synthetic genes, such as sterol regulatory ele-ment-binding protein-1c (SREBP-1c), FAS and Stearoyl-Coenzyme A desaturase 1 (SCD-1), in the liver tissues, while it increased the messenger RAN (mRNA) levels of fatty acid catalytic genes, such as Peroxisome proliferator activated receptor alpha (PPAR-α), acyl-COA oxidase (ACO), and Carnitine palmitoyltransferase-1a (CPT-1a).ConclusionsBased on the results above, HDYST reveals anti-obesity effects declining body fat accumulation through the regulation of fatty acid metabolism and lep-tin/adiponectin serum levels. It therefore suggests that HDYST can be clinically useful for the treatment of obesity. (J Korean Med Rehab 2016;26(1):13-31)
KW - Gami-Handayeolso-Tang (HDYST);Obesity;High fat diet;Lipid accumulation
DO -
UR -
ER -

이하일, 이종하, 권영미 and SONG YUNG SUN. (2016). Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice. Journal of Korean Medicine Rehabilitation, 26(1), 13-31.

이하일, 이종하, 권영미 and SONG YUNG SUN. 2016, "Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice", Journal of Korean Medicine Rehabilitation, vol.26, no.1 pp.13-31.

이하일, 이종하, 권영미, SONG YUNG SUN "Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice" Journal of Korean Medicine Rehabilitation 26.1 pp.13-31 (2016) : 13.

이하일, 이종하, 권영미, SONG YUNG SUN. Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice. 2016; 26(1), 13-31.

이하일, 이종하, 권영미 and SONG YUNG SUN. "Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice" Journal of Korean Medicine Rehabilitation 26, no.1 (2016) : 13-31.

이하일; 이종하; 권영미; SONG YUNG SUN. Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice. Journal of Korean Medicine Rehabilitation, 26(1), 13-31.

이하일; 이종하; 권영미; SONG YUNG SUN. Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice. Journal of Korean Medicine Rehabilitation. 2016; 26(1) 13-31.

이하일, 이종하, 권영미, SONG YUNG SUN. Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice. 2016; 26(1), 13-31.

이하일, 이종하, 권영미 and SONG YUNG SUN. "Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice" Journal of Korean Medicine Rehabilitation 26, no.1 (2016) : 13-31.