@article{ART002076594},
author={박상원 and 이재웅 and 이진호 and 하인혁 and 변장훈 and 정범환 and 정화진 and Lee In Hee and 김민정 and 김은지},
title={Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2016},
volume={26},
number={1},
pages={33-40}
TY - JOUR
AU - 박상원
AU - 이재웅
AU - 이진호
AU - 하인혁
AU - 변장훈
AU - 정범환
AU - 정화진
AU - Lee In Hee
AU - 김민정
AU - 김은지
TI - Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods
JO - Journal of Korean Medicine Rehabilitation
PY - 2016
VL - 26
IS - 1
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 33
EP - 40
SN - 1229-1854
AB - ObjectivesDespite the increasing use of Ja-ha-guh (Hominis-placenta) pharmacopunc-ture in rehabilitative medicine field, its standard compound has yet to be investigated. The purpose of this study is to provide standardization for future studies and increase sat-isfaction of patients by utilizing standard pharmacopuncture.MethodsAlanine and leucine were selected as potential standard compounds. LC/MS was used to devise an analytic method. This analytic method was subject to validation. According to validation guideline of Korea Food and Drug Administration, the specificity, lin-earity, precision, range, quantitative limits, detection limits and accuracy were measured. With this analysis, 3 lots of Ja-ha-guh pharmacopuncture were analyzed.ResultsBecause the specificity, linearity, precision, range, quantitative limits, detection limits and accuracy meet criteria of the guideline, the analytic method was validated. It was found that Ja-ha-guh pharmacopuncture contained 211.02±7.28 ug/ml of alanine and 372.03±7.58 ug/ml of leucine.ConclusionsBoth alanine and leucine appear to be suitable standard compounds. These results are likely to contribute to further standardization of Ja-ha-guh for medical use. (J Korean Med Rehab 2016;26(1):33-40)
KW - Hominis-placenta;Pharmacopuncture;Standardization;LC/MS;alanine;leucine
DO -
UR -
ER -
박상원, 이재웅, 이진호, 하인혁, 변장훈, 정범환, 정화진, Lee In Hee, 김민정 and 김은지. (2016). Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods. Journal of Korean Medicine Rehabilitation, 26(1), 33-40.
박상원, 이재웅, 이진호, 하인혁, 변장훈, 정범환, 정화진, Lee In Hee, 김민정 and 김은지. 2016, "Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods", Journal of Korean Medicine Rehabilitation, vol.26, no.1 pp.33-40.
박상원, 이재웅, 이진호, 하인혁, 변장훈, 정범환, 정화진, Lee In Hee, 김민정, 김은지 "Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods" Journal of Korean Medicine Rehabilitation 26.1 pp.33-40 (2016) : 33.
박상원, 이재웅, 이진호, 하인혁, 변장훈, 정범환, 정화진, Lee In Hee, 김민정, 김은지. Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods. 2016; 26(1), 33-40.
박상원, 이재웅, 이진호, 하인혁, 변장훈, 정범환, 정화진, Lee In Hee, 김민정 and 김은지. "Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods" Journal of Korean Medicine Rehabilitation 26, no.1 (2016) : 33-40.
박상원; 이재웅; 이진호; 하인혁; 변장훈; 정범환; 정화진; Lee In Hee; 김민정; 김은지. Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods. Journal of Korean Medicine Rehabilitation, 26(1), 33-40.
박상원; 이재웅; 이진호; 하인혁; 변장훈; 정범환; 정화진; Lee In Hee; 김민정; 김은지. Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods. Journal of Korean Medicine Rehabilitation. 2016; 26(1) 33-40.
박상원, 이재웅, 이진호, 하인혁, 변장훈, 정범환, 정화진, Lee In Hee, 김민정, 김은지. Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods. 2016; 26(1), 33-40.
박상원, 이재웅, 이진호, 하인혁, 변장훈, 정범환, 정화진, Lee In Hee, 김민정 and 김은지. "Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods" Journal of Korean Medicine Rehabilitation 26, no.1 (2016) : 33-40.
