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Identification of Standard Compound of Ja-ha-guh Pharmacopuncture and Validation of Analytic Methods

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2016, 26(1), pp.33-40
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

박상원 1 이재웅 2 이진호 1 하인혁 1 변장훈 1 정범환 1 정화진 2 Lee In Hee 2 김민정 2 김은지 2

1자생한방병원 한방재활의학과
2자생의료재단 척추관절연구소

Accredited

ABSTRACT

ObjectivesDespite the increasing use of Ja-ha-guh (Hominis-placenta) pharmacopunc-ture in rehabilitative medicine field, its standard compound has yet to be investigated. The purpose of this study is to provide standardization for future studies and increase sat-isfaction of patients by utilizing standard pharmacopuncture.MethodsAlanine and leucine were selected as potential standard compounds. LC/MS was used to devise an analytic method. This analytic method was subject to validation. According to validation guideline of Korea Food and Drug Administration, the specificity, lin-earity, precision, range, quantitative limits, detection limits and accuracy were measured. With this analysis, 3 lots of Ja-ha-guh pharmacopuncture were analyzed.ResultsBecause the specificity, linearity, precision, range, quantitative limits, detection limits and accuracy meet criteria of the guideline, the analytic method was validated. It was found that Ja-ha-guh pharmacopuncture contained 211.02±7.28 ug/ml of alanine and 372.03±7.58 ug/ml of leucine.ConclusionsBoth alanine and leucine appear to be suitable standard compounds. These results are likely to contribute to further standardization of Ja-ha-guh for medical use. (J Korean Med Rehab 2016;26(1):33-40)

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