2014, Vol.14, No.1

Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43

pISSN : 1976-9334 / eISSN : 2288-1522
https://journal.kci.go.kr/jkomor

Objectives: The purpose of this study is to analyse research trends about medical leech in the last10 years. Methods: We searched the papers with key words of ‘medical leech’, ‘水蛭’ in China KnowledgeResource Integrated Database (CNKI), Korean traditional knowledge portal, DBPIA, KISS. Weclassified the papers by year and content. Results: 1. Result of the classification on the basis of the research methods, 50 studies are clinicalcase reports, 301 studies are experimental paper, 599 studies are clinical trial study, 219 studiesare literature review. 2. Result of the classification on the basis of the research topics, 454 studiesare the effect of anticoagulant research, 84 studies are diabetes and renal disease research, 194studies are pharmacological properties research, and 43 studies are effect of allergic andanti-inflammatory research. 3. The proportion of the coagulation effect study tends to decreaseevery year since 2006. 4. Leech research tends to decrease in last 3 years. 5. Recently, there aremany research in psychiatry, orthopedic diseases and beauty. 6. There are 10 studies related toleech in Korean. Conclusions: The researches of medical leech are actively done. The diversity of subjects isgetting wider and richer.

Objectives: This study was performed to evaluate the effects of Metformin and Lonicerae Flos,Agrobacterium Rhizogenes, Coptidis Rhizoma, Atractylodis Rhizoma Alba, Houttuyniae Herbaextracs combinations on hypoglycemia in RAW 264.7 cells. Methods: Expressions of Sirt1, p-adenosine monophosphate-activated kinase (p-AMPK), AMPKalpha,peroxisome proliferator activated receptor (PPAR)-alpha, PPAR-gamma, X-box bindingprotein 1 (XBP-1), tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 were analyzed by realtime polymerase chain reaction and Western blotting analysis. Results: The level of gene expression of Sirt1, p-AMPK, AMPK-alpha, PPAR-alpha and XBP-1 inrelation to that of beta-actin were increased or decreased significantly with the Metformin andLonicerae Flos, Agrobacterium Rhizogenes extracts combination groups. The level of geneexpression of TNF-alpha and IL-6 were increased significantly with the Metformin andHouttuyniae Herba, Coptidis Rhizoma extracts combination groups. Conclusions: Metformin and Lonicerae Flos, Agrobacterium Rhizogenes extracts combinationgroups showed synergistic hypoglycemic effects by increasing AMPK and PPAR gene expressionin RAW 264.7 cells

Objectives: We conducted this study to analysis obesity pattern and obesity related bloodparameters. Methods: A total of 64 overweight and obese (body mass index [BMI] ≥23 cm/kg2) women whohad no other disease was recruited. Body composition and obesity related blood parameters weremeasured. Also subjects were given and filled out the Obesity pattern identification questionnaire. We analyzed the differences of body composition and blood parameters and measuredcorrelations of BMI and blood parameters in each obesity pattern. Results: The distribution of obesity pattern was liver depression (35.6%), food accumulation(47.5%) and deficiency (pi and yang deficiency, 22.0%), in order. There were no significantdifferences age, body composition and obesity related blood parameters between obesitypatterns. BMI and obesity related blood parameters, however, showed significant correlationsdepending on obesity patterns. Conclusions: We concluded that correlations between BMI and obesity related blood parameterswere differed depending on obesity patterns.