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@article{ART001934895},
author={김형구 and Jing-Hua Wang and 채희성 and CHIN, YOUNG-WON and 최한석 and Hojun Kim},
title={Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2014},
volume={14},
number={1},
pages={13-23},
doi={10.15429/jkomor.2014.14.1.13}

TY - JOUR
AU - 김형구
AU - Jing-Hua Wang
AU - 채희성
AU - CHIN, YOUNG-WON
AU - 최한석
AU - Hojun Kim
TI - Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells
JO - Journal of Korean Medicine for Obesity Research
PY - 2014
VL - 14
IS - 1
PB - The Society of Korean Medicine for Obesity Research
SP - 13
EP - 23
SN - 1976-9334
AB - Objectives: This study was performed to evaluate the effects of Metformin and Lonicerae Flos,Agrobacterium Rhizogenes, Coptidis Rhizoma, Atractylodis Rhizoma Alba, Houttuyniae Herbaextracs combinations on hypoglycemia in RAW 264.7 cells. Methods: Expressions of Sirt1, p-adenosine monophosphate-activated kinase (p-AMPK), AMPKalpha,peroxisome proliferator activated receptor (PPAR)-alpha, PPAR-gamma, X-box bindingprotein 1 (XBP-1), tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 were analyzed by realtime polymerase chain reaction and Western blotting analysis. Results: The level of gene expression of Sirt1, p-AMPK, AMPK-alpha, PPAR-alpha and XBP-1 inrelation to that of beta-actin were increased or decreased significantly with the Metformin andLonicerae Flos, Agrobacterium Rhizogenes extracts combination groups. The level of geneexpression of TNF-alpha and IL-6 were increased significantly with the Metformin andHouttuyniae Herba, Coptidis Rhizoma extracts combination groups. Conclusions: Metformin and Lonicerae Flos, Agrobacterium Rhizogenes extracts combinationgroups showed synergistic hypoglycemic effects by increasing AMPK and PPAR gene expressionin RAW 264.7 cells
KW - Metformin;Herbal medicines;Synergistic effects;Combination;Hypoglycemia
DO - 10.15429/jkomor.2014.14.1.13
ER -

김형구, Jing-Hua Wang, 채희성, CHIN, YOUNG-WON, 최한석 and Hojun Kim. (2014). Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells. Journal of Korean Medicine for Obesity Research, 14(1), 13-23.

김형구, Jing-Hua Wang, 채희성, CHIN, YOUNG-WON, 최한석 and Hojun Kim. 2014, "Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells", Journal of Korean Medicine for Obesity Research, vol.14, no.1 pp.13-23. Available from: doi:10.15429/jkomor.2014.14.1.13

김형구, Jing-Hua Wang, 채희성, CHIN, YOUNG-WON, 최한석, Hojun Kim "Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells" Journal of Korean Medicine for Obesity Research 14.1 pp.13-23 (2014) : 13.

김형구, Jing-Hua Wang, 채희성, CHIN, YOUNG-WON, 최한석, Hojun Kim. Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells. 2014; 14(1), 13-23. Available from: doi:10.15429/jkomor.2014.14.1.13

김형구, Jing-Hua Wang, 채희성, CHIN, YOUNG-WON, 최한석 and Hojun Kim. "Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells" Journal of Korean Medicine for Obesity Research 14, no.1 (2014) : 13-23.doi: 10.15429/jkomor.2014.14.1.13

김형구; Jing-Hua Wang; 채희성; CHIN, YOUNG-WON; 최한석; Hojun Kim. Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells. Journal of Korean Medicine for Obesity Research, 14(1), 13-23. doi: 10.15429/jkomor.2014.14.1.13

김형구; Jing-Hua Wang; 채희성; CHIN, YOUNG-WON; 최한석; Hojun Kim. Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells. Journal of Korean Medicine for Obesity Research. 2014; 14(1) 13-23. doi: 10.15429/jkomor.2014.14.1.13

김형구, Jing-Hua Wang, 채희성, CHIN, YOUNG-WON, 최한석, Hojun Kim. Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells. 2014; 14(1), 13-23. Available from: doi:10.15429/jkomor.2014.14.1.13

김형구, Jing-Hua Wang, 채희성, CHIN, YOUNG-WON, 최한석 and Hojun Kim. "Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells" Journal of Korean Medicine for Obesity Research 14, no.1 (2014) : 13-23.doi: 10.15429/jkomor.2014.14.1.13