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A Study on the Acute Toxicity of Bangpungtongsung-san(Fangfengtongsheng-San) in Mice

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2009, 9(1), pp.71-78
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine

이재훈 1 Ki-suck Shim 1 Hwayong Park 1 전원경 1 엄영란 1 마진열 1

1한국한의학연구원

Candidate

ABSTRACT

Objectives Bangpungtongsung-san(Fangfengtongsheng-san) has been traditionally prescribed a a restorative medicine. Methods In this study, we investigated the acute toxicity of water-extracted Bangpungtongsung-san(Fangfengtongsheng-san). 20 male and 20 female mice were orally treated of Bangpungtongsung-san(Fangfengtongsheng-san) at the respective doses of 0 (control group), 1250, 2500 and 5000mg/kg for 14 days. Results We observed survival rates, general toxicity, change of body weight and examined microscopic changes of some organs. Conclusions Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000mg/kg). LD50 of Bangpungtongsung-san(Fangfengtongsheng-san) might be over 5000mg/kg and it was very safe to ICR mice.

Citation status

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