@article{ART001954285},
author={이신지 and Shambhunath Bose and 이수진 and 정지은 and Byung-soo Koo and Kim, Dong il and Hojun Kim},
title={Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2013},
volume={2},
number={2},
pages={74-83}
TY - JOUR
AU - 이신지
AU - Shambhunath Bose
AU - 이수진
AU - 정지은
AU - Byung-soo Koo
AU - Kim, Dong il
AU - Hojun Kim
TI - Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes
JO - Journal of Korean Medicine for Obesity Research
PY - 2013
VL - 2
IS - 2
PB - The Society of Korean Medicine for Obesity Research
SP - 74
EP - 83
SN - 1976-9334
AB - Objectives: This study was performed to evaluate the effects of fermented lotus extracts on theinhibition of differentiation in 3T3-L1 preadipocytes.
Methods: Extracts of lotus leaf and lotus root were fermented using 4 different probioticsseparately, including Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve,and Bifidobacterium longum. Inhibition of preadipocyte differentiation was examined by Oil red Odye staining. Expressions of adipogenic transcription factors including CCAAT/enhancer bindingproteins (C/EBPα) and peroxisome proliferators-activated receptor γ (PPARγ) were analyzed byreal time polymerase chain reaction and Western blotting analysis.
Results: Fermented lotus extracts inhibited adipogenic transcription factors by inhibitingpreadipocytes differentiation. All of the groups fermented by 4 kinds of probiotics showedreduction in Oil Red O dye staining. Bifidobacterium breve showed the most effective inhibitionof C/EBPα. Bifidobacterium breve and Bifidobacterium longum showed the best downregulationof PPARγ expressions compared with the control and the unfermented lotus group.
Conclusions: Fermented lotus extracts showed significant effects on inhibition of preadipocytedifferentiation in 3T3-L1 preadipocytes showing correlation with insulin sensitivity and lipidmetabolism related with obesity.
KW - 3T3-L1 preadipocyte;Lotus;Probiotics;Fermentation;Obesity;Insulin resistance
DO -
UR -
ER -
이신지, Shambhunath Bose, 이수진, 정지은, Byung-soo Koo, Kim, Dong il and Hojun Kim. (2013). Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes. Journal of Korean Medicine for Obesity Research, 2(2), 74-83.
이신지, Shambhunath Bose, 이수진, 정지은, Byung-soo Koo, Kim, Dong il and Hojun Kim. 2013, "Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes", Journal of Korean Medicine for Obesity Research, vol.2, no.2 pp.74-83.
이신지, Shambhunath Bose, 이수진, 정지은, Byung-soo Koo, Kim, Dong il, Hojun Kim "Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes" Journal of Korean Medicine for Obesity Research 2.2 pp.74-83 (2013) : 74.
이신지, Shambhunath Bose, 이수진, 정지은, Byung-soo Koo, Kim, Dong il, Hojun Kim. Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes. 2013; 2(2), 74-83.
이신지, Shambhunath Bose, 이수진, 정지은, Byung-soo Koo, Kim, Dong il and Hojun Kim. "Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes" Journal of Korean Medicine for Obesity Research 2, no.2 (2013) : 74-83.
이신지; Shambhunath Bose; 이수진; 정지은; Byung-soo Koo; Kim, Dong il; Hojun Kim. Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes. Journal of Korean Medicine for Obesity Research, 2(2), 74-83.
이신지; Shambhunath Bose; 이수진; 정지은; Byung-soo Koo; Kim, Dong il; Hojun Kim. Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes. Journal of Korean Medicine for Obesity Research. 2013; 2(2) 74-83.
이신지, Shambhunath Bose, 이수진, 정지은, Byung-soo Koo, Kim, Dong il, Hojun Kim. Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes. 2013; 2(2), 74-83.
이신지, Shambhunath Bose, 이수진, 정지은, Byung-soo Koo, Kim, Dong il and Hojun Kim. "Effects of Fermented Lotus Extracts on the Differentiation in 3T3-L1 Preadipocytes" Journal of Korean Medicine for Obesity Research 2, no.2 (2013) : 74-83.