Comparison of Gangji-hwan-1, 2, 3, 4 and Combination of Gangji-hwan-1 and Gamisoche-hwan in the Reducing Effects of Body Weight in a High Fat Diet-Fed Obese Mice (고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 降脂丸-1, 2, 3, 4와 降脂丸-1合加味消滯丸의 체중감량효과 비교)

Jae Sang Yoo (유재상); Ja Ryong Ku (구자룡); Ki Hyeon Yoon (윤기현); 조주흠; Du Hyon Jang (장두현); 정양삼; Jong Hoon Kim (김종훈); Byeong Chul Kim (김병출); Hoa Jun Seok (석화준); 윤미정; Jong Seong Roh (노종성); Shin Soon Shik (신순식)

Comparison of Gangji-hwan-1, 2, 3, 4 and Combination of Gangji-hwan-1 and Gamisoche-hwan in the Reducing Effects of Body Weight in a High Fat Diet-Fed Obese Mice

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2015, 15(1), pp.9~23
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Published : June 30, 2015

Jae Sang Yoo ¹, Ja Ryong Ku ², Ki Hyeon Yoon ³, 조주흠 ⁴, Du Hyon Jang ⁵, 정양삼 ⁶, Jong Hoon Kim ⁷, Byeong Chul Kim ⁸, Hoa Jun Seok ⁹, 윤미정 ¹⁰, Jong Seong Roh ¹¹, Shin Soon Shik ¹²

¹봉황한의원
²소리청한의원
³동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소
⁴동의대학교 한의과대학
⁵청남한의원
⁶정양삼한의원
⁷능인한의원
⁸고려한의원
⁹수정한의원
¹⁰목원대학교 테크노과학대학 바이오건강학부
¹¹동의대학교 한의과대학 방제학교실
¹²동의대학교

Withdraw

이 논문은 한방비만학회 연구윤리위원회 심의(2021.07.13.) 결과 데이터 중복 사용 및 인용 표시가 없는 자기 인용이 확인되어 게재가 철회된 논문임.

ABSTRACT

Objectives: This study was investigated the improvement effects of Pakistani Ephedra herba- containing Gangji-hwan-1, 2, 3 (Di-fatty; DF-1, 2, 3), Chinese Ephedra herba-containing Gangji- hwan-4 (DF-4) and combination of DF-1 and Gamisoche-hwan (GSH) on obesity in a high fat diet-fed obese mouse model.Methods: Eight-week-old C57BL/6N mice were divided into seven groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-1, 2, 3, 4, and DF-1+GSH groups given a high fat diet with DF-1, 2, 3, 4 (40, 80, 160, 80 mg/kg), and DF-1+ GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio (FER), blood lipid markers, liver histology, and fat weight and histology were examined.Results: Body weight gain was significantly decreased in DF and DF-1+GSH groups compared with control. The extent of decreases was eminent in DF-1+GSH group. FER and circulating concentration of leptin were decreased in DF and DF-1+GSH groups compared with control. Circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF-1+GSH groups compared with control. The size of adipocytes were decreased by DF and DF-1+GSH groups compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF-1+GSH groups decreased the number of large adipocytes.Conclusions: In conclusion, these results suggest that DF and DF-1+GSH groups decrease FER, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain. In addition, these effects were more effective in DF-1+GSH combination group than in DF-1, 2, 3, 4 groups.

KEYWORDS

Gangji-hwan, Gamisoche-hwan, Pakistani Ephedra Herba, Chinese Ephedra Herba, Obesity, Leptin

Citation status

* References for papers published after 2024 are currently being built.

[other] Korean Society for the Study of Obesity / 2012 / Obesity treatment guidelines 2012 / Korean Society for the Study of Obesity : 14~

[report] Korea Centers for Disease Control & Prevention / 2013 / Korea Health Statistics 2013: Korea National Health and Nutrition Examination Survey [KNHANES VI-1] / Korea Centers for Disease Control & Prevention : 50~51

[journal] 안예지 / 2014 / Gangjihwan Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed C57BL/6N Mice / 대한본초학회지 / 대한본초학회 29(2) : 47~54

[journal] 조주흠 / 2014 / Comparison of Pakistani and Chinese Ephedra Herba-Containing Gangjihwan in the Improvement Effects of Nonalcoholic Fatty Liver Disease in a High Fat Diet-Fed NAFLD Mouse Model / 대한한의학 방제학회지 / 대한한의학방제학회 22(1) : 113~122

[journal] 정양삼 / 2014 / Comparison of Gangjihwan-1,2,3,4 and Combination of Gangjihwan-1 and Gamisochehwanin the Improvement Effects of Nonalcoholic Fatty Liver Disease in a High Fat Diet-Fed Obese Mouse Model / 대한본초학회지 / 대한본초학회 29(6) : 149~156

[journal] 김병출 / 2014 / Comparison of Pakistani Ephedra Herba and Chinese Ephedra Herba Containing Gangjihwan in the Improvement Effects of Weight Loss in a High Fat Diet-Fed Obese Mice / 대한한의학 방제학회지 / 대한한의학방제학회 22(2) : 63~76

[book] Yun GY / 1985 / Clinical formula science of Korean medicine / Myeongbo Press : 387~

[journal] 석화준 / 2014 / Comparison of Gangjihwan and Combination of Gangjihwan and Gamisochehwanin the Improvement Effects of Weight Loss in a High Fat Diet-Fed Obese Mice / 대한한의학 방제학회지 / 대한한의학방제학회 22(2) : 105~120

[journal] 장두현 / 2014 / Comparison of Gangjihwan and Combination of Gangjihwan and Gamisochehwanin the Improvement Effects of Nonalcoholic Fatty Liver Disease in a High Fat Diet-Fed NAFLD Mouse Model / 대한한의학 방제학회지 / 대한한의학방제학회 22(1) : 167~176

[journal] Shinwari ZK / 2003 / Sustainable harvest of medicinal plants at Bulashbar Nullah, Astore (Northern Pakistan) / J Ethnopharmacol 84(2-3) : 289~298

[web] Humanherb / 2012 / Gyeongsan: Humanherb / http://humanherb.co.kr/bbs/view.php?id=news&no=319

[journal] Oh JS / 2014 / The anti-obesity effects of the dietary combination of fermented red ginseng with levan in high fat diet mouse model / Phytother Res 28(4) : 617~622

[journal] Shekelle PG / 2003 / Efficacy and safety of ephedra and for weight loss and athletic performance: a meta-analysis / JAMA 289(12) : 1537~1545

[journal] Pittler MH / 2004 / Dietary supplements for body-weight reduction: a systemic review / Am J Clin Nutr 79(4) : 529~536

[journal] Haller CA / 2000 / Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids / N Engl J Med 343(25) : 1833~1838

[journal] Fried SK / 2000 / Regulation of leptin production in humans / J Nutr 130(12) : 3127S~3131S

[journal] Brochu-Gaudreau K / 2010 / Adiponectin action from head to toe / Endocrine 37(1) : 11~32

[journal] Waki H / 2003 / Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin / J Biol Chem 278(41) : 40352~40363

[journal] Lee MH / 2008 / Biochemistry / Biochemistry 47(44) : 11682~11692

[journal] Kern PA / 2003 / Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression / Diabetes 52(7) : 1779~1785

[journal] Lee B / 2014 / Adiponectin and energy homeostasis / Rev Endocr Metab Disord 15(2) : 149~156

[journal] Ohashi K / 2012 / Anti-inflammatory and anti-atherogenic properties of adiponectin / Biochimie 94(10) : 2137~2142

[journal] Daniele A / 2008 / Analysis of adiponectin gene and comparison of its expression in two different pig breeds / Obesity (Silver Spring) 16(8) : 1869~1874

[journal] De Rosa A / 2013 / Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects / Eur J Endocrinol 169(1) : 37~43

[journal] Woods SC / 2000 / Adiposity signals and the control of energy homeostasis / Nutrition 16(10) : 894~902

[journal] Brown LM / 2006 / Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice / Physiol Behav 89(5) : 687~691

[journal] Porte D Jr / 1998 / Obesity, diabetes and the central nervous system / Diabetologia 41(8) : 863~881

[journal] Schwartz MW / 1992 / Insulin in the brain: a hormonal regulator of energy balance / Endocr Rev 13(3) : 387~414

[journal] Woods SC / 1998 / Signals that regulate food intake and energy homeostasis / Science 280(5368) : 1378~1383

This paper was written with support from the National Research Foundation of Korea.

KJCKorea
Journal Central

Journal of Korean Medicine for Obesity Research 2024 KCI Impact Factor : 0.83