Comparison of Gangji-hwan-1, 2, 3, 4 and Combination of Gangji-hwan-1 and Gamisoche-hwan in the Reducing Effects of Body Weight in a High Fat Diet-Fed Obese Mice (고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 降脂丸-1, 2, 3, 4와 降脂丸-1合加味消滯丸의 체중감량효과 비교)

Jae Sang Yoo (유재상); Ja Ryong Ku (구자룡); Ki Hyeon Yoon (윤기현); 조주흠; Du Hyon Jang (장두현); 정양삼; Jong Hoon Kim (김종훈); Byeong Chul Kim (김병출); Hoa Jun Seok (석화준); 윤미정; Jong Seong Roh (노종성); Shin Soon Shik (신순식)

Comparison of Gangji-hwan-1, 2, 3, 4 and Combination of Gangji-hwan-1 and Gamisoche-hwan in the Reducing Effects of Body Weight in a High Fat Diet-Fed Obese Mice

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2015, 15(1), pp.9-23
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Published : June 30, 2015

Jae Sang Yoo ¹, Ja Ryong Ku ², Ki Hyeon Yoon ³, 조주흠 ⁴, Du Hyon Jang ⁵, 정양삼 ⁶, Jong Hoon Kim ⁷, Byeong Chul Kim ⁸, Hoa Jun Seok ⁹, 윤미정 ¹⁰, Jong Seong Roh ¹¹, Shin Soon Shik ¹²

¹봉황한의원
²소리청한의원
³동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소
⁴동의대학교 한의과대학
⁵청남한의원
⁶정양삼한의원
⁷능인한의원
⁸고려한의원
⁹수정한의원
¹⁰목원대학교 테크노과학대학 바이오건강학부
¹¹동의대학교 한의과대학 방제학교실
¹²동의대학교

Withdraw

이 논문은 한방비만학회 연구윤리위원회 심의(2021.07.13.) 결과 데이터 중복 사용 및 인용 표시가 없는 자기 인용이 확인되어 게재가 철회된 논문임.

ABSTRACT

Objectives: This study was investigated the improvement effects of Pakistani Ephedra herba- containing Gangji-hwan-1, 2, 3 (Di-fatty; DF-1, 2, 3), Chinese Ephedra herba-containing Gangji- hwan-4 (DF-4) and combination of DF-1 and Gamisoche-hwan (GSH) on obesity in a high fat diet-fed obese mouse model.Methods: Eight-week-old C57BL/6N mice were divided into seven groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-1, 2, 3, 4, and DF-1+GSH groups given a high fat diet with DF-1, 2, 3, 4 (40, 80, 160, 80 mg/kg), and DF-1+ GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio (FER), blood lipid markers, liver histology, and fat weight and histology were examined.Results: Body weight gain was significantly decreased in DF and DF-1+GSH groups compared with control. The extent of decreases was eminent in DF-1+GSH group. FER and circulating concentration of leptin were decreased in DF and DF-1+GSH groups compared with control. Circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF-1+GSH groups compared with control. The size of adipocytes were decreased by DF and DF-1+GSH groups compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF-1+GSH groups decreased the number of large adipocytes.Conclusions: In conclusion, these results suggest that DF and DF-1+GSH groups decrease FER, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain. In addition, these effects were more effective in DF-1+GSH combination group than in DF-1, 2, 3, 4 groups.

KEYWORDS

Gangji-hwan, Gamisoche-hwan, Pakistani Ephedra Herba, Chinese Ephedra Herba, Obesity, Leptin

Citation status

* References for papers published after 2023 are currently being built.

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This paper was written with support from the National Research Foundation of Korea.

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