Effects of Citri Reticulatae Viride Pericarpium on 4-Hydroxynonenal-Induced Inflammation in PC12 Cells (청피의 항염증효과)

Young Jun Ye (예영준); Kim Youn Sub (김연섭); Mi Suk Kang (강미숙)

Effects of Citri Reticulatae Viride Pericarpium on 4-Hydroxynonenal-Induced Inflammation in PC12 Cells

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2016, 16(2), pp.79-82
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Published : December 30, 2016

Young Jun Ye ¹, Kim Youn Sub ², Mi Suk Kang ²

¹가천대학교 한의과대학 해부경혈학교실
²가천대학교

Accredited

ABSTRACT

Objectives: The purpose of this study was to observe the effects of Citri Reticulatae ViridePericarpium (CP) on 4-Hydroxynonenal (4-HNE)-induced inflammation in PC12 cells. Methods: 4-HNE was treated in PC12 cell to cause inflammatory response, and then treated withCP water extract at 25, 50, and 100 g/ml. The phosphorylation of Jun N-terminal kinase (JNK)and the expression of NF-B in PC12 cells were determined by Western blot, respectively. Results: The phosphorylation of JNK was significantly decreased in 4-HNE-stimulated PC12 cellby the treatment of CP extract at 25 g/ml. The 4-HNE-induced expression of nuclear factorkappa-light-chain-enhancer of activated B cells (NF-B) p65 in nuclear of the cells wassignificantly decreased in PC12 cell by treatment with CP extract at 25, 50, and 100 g/ml. Conclusions: These results suggest that CP water extract has an anti-inflammatory activitythrough suppressing the JNK and NF-B activation.

KEYWORDS

Citri Reticulatae Viride Pericarpium, 4-HNE, pJNK, pNF-kB

Citation status

* References for papers published after 2023 are currently being built.

[journal] Whitney NP / 2009 / Inflammation mediates varying effects in neurogenesis:relevance to the pathogenesis of brain injury and neurodegenerative disorders / J Neurochem 108(6) : 1343~1359

[journal] Kannappan R / 2011 / Neuroprotection by spice-derived nutraceuticals : you are what you eat! / Mol Neurobiol 44(2) : 142~159

[journal] Siddiqui MA / 2012 / Short-term exposure of 4-hydroxynonenal induces mitochondria-mediated apoptosis in PC12 cells / Hum Exp Toxicol 31(4) : 336~345

[journal] Bruckner SR / 2002 / JNK3 contributes to c-jun induction and apoptosis in 4-hydroxynonenal-treated sympathetic neurons / J Neurosci Res 70(5) : 665~670

[journal] Yin G / 2015 / Lipid peroxidation-mediated inflammation promotes cell apoptosis through activation of NF-B pathway in rheumatoid arthritis synovial cells / Mediators Inflamm : 460310~

[journal] Mattson MP / 2009 / Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders / Exp Gerontol 44(10) : 625~633

[journal] Purkayastha S / 2013 / Disruption of neurogenesis by hypothalamic inflammation in obesity or aging / Rev Endocr Metab Disord 14(4) : 351~356

[thesis] Ham MR / 2013 / Role of macrophage glucose-6-phosphate dehydrogenase in proinflammatory responses and oxidative stress associated with obesity / Doctor / Seoul University

[journal] 조완주 / 2013 / Effects of Combined and Walking Exercises on Inflammatory Markers in Obese Middle-Aged Women / 한국스포츠학회 / 한국스포츠학회 11(1) : 251~263

[book] Oriental University Edit Committee / 2011 / Herbology / YoungLim Co : 217~

[journal] Baik SO / 2001 / Analysis and quantitative distribution of glycosided flavonoids in citruses and Korean Chung-pi / Anal Sci Technol 14(4) : 340~348

[journal] Min SS / 2008 / Antioxidant activities of citrus herbal product extracts / Food Chem 111 : 892~896

[journal] Li X / 2013 / Protective effect against hydroxylinduced DNA damage and antioxidant activity of citri reticulatae pericarpium / Adv Pharm Bull 3(1) : 175~181

[journal] 노영호 / 2002 / Experimental Study of Fraction of Citri Reticulatae Viride Pericarpium extract on the Brain Damage in Cerebral Ischemia / 동의생리병리학회지 / 한의병리학회 16(5) : 10~898

[journal] Kim DK / 1999 / Anti-allergic components from the peels of Citrus unshiu / Arch Pharm Res 22(6) : 642~645

[journal] 이해자 / 2006 / Effects of Citri Reticulatae Viride Pericarpium on the Vascular Endothelial Growth Factor(VEGF) in the bronchial asthma mouse model / 대한한방소아과학회지 / 대한한방소아과학회 20(1) : 181~194

[journal] Jeong HY / 1998 / Effect of Citri Reticulatae Viride Pericarpium water extract on immunocytes in mice / Korean J Orient Med Pathol 12 : 55~62

[thesis] Jung SY / 2013 / Anti-obesity effect of Citrus unshiu peel in rats fed a high-fat diet / Master / Kyunghee University

[journal] 조현균 / 2015 / Ethanol Extracts of Citrus Peel Inhibits Adipogenesis through AMPK Signaling Pathway in 3T3-L1 Preadipocytes / 생명과학회지 / 한국생명과학회 25(3) : 285~292

[thesis] Choi ES / 2014 / Effect of citri unshiu pericarpium and citri unshiu pericarpium immaturus on differentiation of pre-adipocyte / Master / Wonkwang University

[thesis] Joo KG / 2016 / Effects of Citri Reticulatae Viride Pericarpium on apoptosis in PC-12 cell / Master / Gachon University

[journal] Xie QW / 1994 / Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase / J Biol Chem 269(7) : 4705~4708

[journal] Fu J / 2016 / Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IB/NF-B signaling / Environ Toxicol Pharmacol 6 : 241~250

[journal] Yoon JH / 2014 / P coumaric acid and ursolic acid from corni fructus attenuated amyloid25−35-induced toxicity through regulation of the NF-B signaling pathway in PC12 cells / J Agric Food Chem 62(21) : 4911~4916

[journal] Kang SY / 2014 / Effect of the semen extract of Cuscuta chinensis on inflammatory responses in LPS-stimulated BV-2 microglia / Chin J Nat Med 12(8) : 573~581

[journal] Caivano M / 1998 / Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages / FEBS Lett 429(3) : 249~253

[journal] Nolan GP / 1991 / DNA binding and IB inhibition of the cloned p65 subunit of NF-B, a rel-related polypeptide / Cell 64(5) : 961~969

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