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@article{ART002235181},
author={이귀선 and 김두희 and 박중현 and 최희승 and 허성규 and Cha Yun Yeop},
title={The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2017},
volume={17},
number={1},
pages={1-9}

TY - JOUR
AU - 이귀선
AU - 김두희
AU - 박중현
AU - 최희승
AU - 허성규
AU - Cha Yun Yeop
TI - The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells
JO - Journal of Korean Medicine for Obesity Research
PY - 2017
VL - 17
IS - 1
PB - The Society of Korean Medicine for Obesity Research
SP - 1
EP - 9
SN - 1976-9334
AB - Objectives: This study was performed to identify the anti-inflammatory effect of Pulsatilla koreana (PK) methanol extract on lipopolysaccharide (LPS) induced inflammatory. Methods: There were five groups. They were control group, LPS-exposed PK methanol extract group (0 mg/ml, 10 mg/ml, 30 mg/ml, 100 mg/ml). To measure out cytotoxicity of PK, we performed the MTT assay. To evaluate the anti-inflammatory effect of PK, we examined the inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), and pro- inflammatory cytokines (interleukin [IL]-1b, IL-6, tumor necrosis factor-a [TNF-a], IL-10). Results: 1. The extract of PK (∼100 mg/ml) itself did not have any cytotoxic effect in RAW 264.7 cells. 2. The concentration of plasma NO and PGE2 in PK methanol extract group showed a lower values than those of control group. 3. The concentration of plasma IL-1b, plasma IL-6, and plasma TNF-a in PK methanol extract group showed a lower values than those of control group. 4. The concentration of Plasma IL-10 in PK methanol extract groups showed higher than control group; however, these values showed no significantly different. Conclusions: According to this study, the extract of PK could be used as a protective agent against inflammation.
KW - Pulsatilla koreana;Lipopolysaccharide;RAW264.7;Anti-inflammatory effect;Cytokines
DO -
UR -
ER -

이귀선, 김두희, 박중현, 최희승, 허성규 and Cha Yun Yeop. (2017). The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells. Journal of Korean Medicine for Obesity Research, 17(1), 1-9.

이귀선, 김두희, 박중현, 최희승, 허성규 and Cha Yun Yeop. 2017, "The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells", Journal of Korean Medicine for Obesity Research, vol.17, no.1 pp.1-9.

이귀선, 김두희, 박중현, 최희승, 허성규, Cha Yun Yeop "The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells" Journal of Korean Medicine for Obesity Research 17.1 pp.1-9 (2017) : 1.

이귀선, 김두희, 박중현, 최희승, 허성규, Cha Yun Yeop. The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells. 2017; 17(1), 1-9.

이귀선, 김두희, 박중현, 최희승, 허성규 and Cha Yun Yeop. "The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells" Journal of Korean Medicine for Obesity Research 17, no.1 (2017) : 1-9.

이귀선; 김두희; 박중현; 최희승; 허성규; Cha Yun Yeop. The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells. Journal of Korean Medicine for Obesity Research, 17(1), 1-9.

이귀선; 김두희; 박중현; 최희승; 허성규; Cha Yun Yeop. The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells. Journal of Korean Medicine for Obesity Research. 2017; 17(1) 1-9.

이귀선, 김두희, 박중현, 최희승, 허성규, Cha Yun Yeop. The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells. 2017; 17(1), 1-9.

이귀선, 김두희, 박중현, 최희승, 허성규 and Cha Yun Yeop. "The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells" Journal of Korean Medicine for Obesity Research 17, no.1 (2017) : 1-9.