@article{ART002235183},
author={CHANG SEJU and 왕경화 and Choi, Han-Seok and CHIN, YOUNG-WON and Hojun Kim},
title={The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2017},
volume={17},
number={1},
pages={20-28}
TY - JOUR
AU - CHANG SEJU
AU - 왕경화
AU - Choi, Han-Seok
AU - CHIN, YOUNG-WON
AU - Hojun Kim
TI - The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice
JO - Journal of Korean Medicine for Obesity Research
PY - 2017
VL - 17
IS - 1
PB - The Society of Korean Medicine for Obesity Research
SP - 20
EP - 28
SN - 1976-9334
AB - Objectives: The purpose of this study was to investigate anti-obesity effect of Scutellariae Radix extract combined with metformin.
Methods: Male C57BL/6 mice, 4 weeks of age, were used to set high-fat diet induced obesity model. They were grouped NOR (normal control), HFD (high fat diet control), MET (metformin, 100 mg/kg/day), MH2 (metformin 50 mg/kg/day+Scutellariae Radix 200 mg/kg/day), and HG4 (Scutellariae Radix 400 mg/kg/day). MET, MH2, and HG4 were orally administered for 10 weeks. Body weight was measured every week. Fasting blood glucose, triglyceride, total cholesterol (TC), high density lipoprotein, glutamic oxaloacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) were measured before sacrifice. Oral glucose tolerance test (OGTT) was also performed. Organ weight and internal fat weight were measured after sacrifice.
Results: MH2 group showed a reduction of body weight when compared with HFD group. MH2 group showed stable blood level control which was calculated areas under the curves by OGTT. TC, GOT, GPT level, internal fat, and organ weight in MH2 group reduced.
Conclusions: The combined treatment of Scutellariae Radix and Metformin has impact on treating obesity. Further studies are needed to evaluate the effect of Metformin and herbal medicine combination therapy.
KW - Scutellaria bacalensis;Metformin;Obesity;High fat diet;C57BL/6 mice
DO -
UR -
ER -
CHANG SEJU, 왕경화, Choi, Han-Seok, CHIN, YOUNG-WON and Hojun Kim. (2017). The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice. Journal of Korean Medicine for Obesity Research, 17(1), 20-28.
CHANG SEJU, 왕경화, Choi, Han-Seok, CHIN, YOUNG-WON and Hojun Kim. 2017, "The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice", Journal of Korean Medicine for Obesity Research, vol.17, no.1 pp.20-28.
CHANG SEJU, 왕경화, Choi, Han-Seok, CHIN, YOUNG-WON, Hojun Kim "The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice" Journal of Korean Medicine for Obesity Research 17.1 pp.20-28 (2017) : 20.
CHANG SEJU, 왕경화, Choi, Han-Seok, CHIN, YOUNG-WON, Hojun Kim. The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice. 2017; 17(1), 20-28.
CHANG SEJU, 왕경화, Choi, Han-Seok, CHIN, YOUNG-WON and Hojun Kim. "The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice" Journal of Korean Medicine for Obesity Research 17, no.1 (2017) : 20-28.
CHANG SEJU; 왕경화; Choi, Han-Seok; CHIN, YOUNG-WON; Hojun Kim. The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice. Journal of Korean Medicine for Obesity Research, 17(1), 20-28.
CHANG SEJU; 왕경화; Choi, Han-Seok; CHIN, YOUNG-WON; Hojun Kim. The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice. Journal of Korean Medicine for Obesity Research. 2017; 17(1) 20-28.
CHANG SEJU, 왕경화, Choi, Han-Seok, CHIN, YOUNG-WON, Hojun Kim. The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice. 2017; 17(1), 20-28.
CHANG SEJU, 왕경화, Choi, Han-Seok, CHIN, YOUNG-WON and Hojun Kim. "The Effect of Scutellariae Radix Combined with Metformin on Obesity-Relating Biomarker in High Fat Fed C57BL/6 Mice" Journal of Korean Medicine for Obesity Research 17, no.1 (2017) : 20-28.