Analysis of Adverse Events in Weight Loss Program in Combination with ‘Gamitaeeumjowee-Tang’ and Low-Calorie Diet (가미 태음조위탕과 저열량 식이를 병행한 체중 감량 프로그램에서 발생한 이상 반응 분석)

윤나라; Yeong-Jae Yoo (유영재); Min-Ji Kim (김민지); Seo-Young Kim (김서영); Young-Woo Lim (임영우); Lim Hyung Ho (임형호); Young-Bae Park (박영배)

doi:10.15429/jkomor.2018.18.1.1

Analysis of Adverse Events in Weight Loss Program in Combination with ‘Gamitaeeumjowee-Tang’ and Low-Calorie Diet

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2018, 18(1), pp.1-9
DOI : 10.15429/jkomor.2018.18.1.1
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Published : June 30, 2018

윤나라 ¹, Yeong-Jae Yoo ¹, Min-Ji Kim ¹, Seo-Young Kim ¹, Young-Woo Lim ¹, Lim Hyung Ho ², Young-Bae Park ³

¹누베베 한의원
²가천대학교
³누베베 미병 의학 연구소

Accredited

ABSTRACT

Objectives: The objective of this study was to assess the safety of 'Gamitaeeumjowee-tang' by analyzing adverse events in weight loss program in combination with 'Gamitaeeumjowee- tang' and low-calorie diet. Methods: A retrospective review of adverse events in weight loss program in combination with 'Gamitaeeumjowee-tang' and low-calorie diet from the electronic medical chart (n=124) between June 2015 and December 2016 was conducted. Three Korean Medicine Doctors (KMDs) reviewed adverse events for two times, during week 2 to 4 and at week 10, after starting weight loss program. Adverse events were evaluated in terms of causality, severity and system-organ classes. Also, agreement among the three KMDs was made through further discussion in case of disagreement after independent review. Results: The overall rate of adverse events was 37.1% during week 2 to 4 and 16.9% at week 10. For causality of adverse events using the World Health Organization-Uppsala Monitoring Centre causality categories, 52.2% were evaluated 'possible' at week 2-4 and 57.1% were evaluated 'unlikely' at week 10. All symptoms were evaluated as 'mild' by LDS scale. Nausea (15, 12.1%) was the most frequent adverse event at week 2-4 and dizziness (6, 4.8%) was the most common at week 10. Conclusions: Adverse events decreased over time. There were no serious adverse events and none of the subjects were dropped due to adverse events. Continuous study is needed to prove the safety of 'Gamitaeeumjowee-tang' for treating obesity.

KEYWORDS

Gamitaeeumjowee-tang, Adverse drug event, Safety, Weight loss program, Low-calorie diet

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* References for papers published after 2023 are currently being built.

[book] Korean Society for the Study of Obesity / 2008 / Clinical bariatrics / Korea Medical Book : 143~

[web] Ministry of Health and Welfare / 2016 / Korea Health Statistics 2016: Korea National Health Statistics and Nutrition Examination Survey (KNHANESVII-1) / KCDC / https://knhanes.cdc.go.kr/knhanes/sub04/sub04_03.do?classType=7

[confproc] Korean Society for Health Promotion and Disease Prevention / 2012 / / Korean Society for Health Promotion and Disease Prevention 2012 spring academic conference / Korean Society for Health Promotion and Disease Prevention : 163~168

[journal] 김경곤 / 2015 / Safety of Anti-Obesity Drugs Approved for Long-Term Use / Journal of Obesity & Metabolic Syndrome / 대한비만학회 24(1) : 17~27

[journal] 정장원 / 2016 / Trend Research of the Human Body-Oriented Obesity Studies on Korean Medicine / 한방재활의학과학회지 / 한방재활의학과학회 26(1) : 49~61

[journal] Hwang MJ / 2007 / Literature review of herbal medicines on treatment of obesity since 2000; mainly about Ephedra Herba / J Korean Med Obes Res 7(1) : 39~54

[book] Lee JM / 1993 / Longevity and life preservation in Eastern medicine. 2nd. / Hanglimsa : 19~

[journal] 박경무 / 2009 / Review on the Research Relative to Taeeumjowui-Tang(Taiyintiaowei-tang) / 한방비만학회지 / 한방비만학회 9(1) : 23~36

[journal] 이지은 / 2010 / Clinical Trial of Taeeumjowui -Tang(Taiyintiaowei-tang) on Obese Patients - Randomized, Double Blind, Placebo-Controlled Study - / 한방재활의학과학회지 / 한방재활의학과학회 20(4) : 197~213

[journal] Park SJ / 2013 / Efficacy and safety of taeeumjowi-tang in obese Korean adults: a double-blind, randomized, and placebo-controlled pilot trial / Evid Based Complement Alternat Med 2013

[journal] 서남준 / 2008 / Clinical Study of Gamitaeeumjowi-tang for Obese Patients / 동의생리병리학회지 / 한의병리학회 22(2) : 446~452

[journal] Song MY / 2006 / The safety guidelines for use of Ma-huang in obesity treatment / J Korean Med Obes Res 6(2) : 17~27

[book] Korea Institute of Oriental Medicine / 2016 / KMCPG-obesity / Elsevier Korea : 84~89

[book] Korean Society for the Study of Obesity / 2012 / Clinical Practice Guidelines for Obesity 2012 / KOSSO : 61~71

[web] World Health Organization-Uppsala Monitoring Centre (WHO-UMC) / 2018 / Causality categories / World Health Organization-Uppsala Monitoring Centre (WHO-UMC) / https://who-umc.org/media/164200/who-umc-causality-assessment_new-logo.pdf.

[report] Korea Institute of Drug Safety & Risk Management / 2013 / Adverse Drug Reaction Assessment Report / Korea Institute of Drug Safety & Risk Management : 60~63

[journal] 김미경 / 2015 / Analysis of Herbal-drug-associated Adverse Drug Reactions Using Data from Spontaneous Reporting System in Electronic Medical Records / 대한한의학회지 / 대한한의학회 36(1) : 45~60

[journal] Kyung EJ / 2013 / Evaluation of adverse reactions to contrast media in the hospital / Br J Radiol 86(1032) : 20130418~

[journal] Classen DC / 1997 / Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality / JAMA 277 : 301~306

[report] Korea Institute of Drug Safety & Risk Management / 2014 / Terminology Guide for Reporting Adverse Drug Reactions / Korea Institute of Drug Safety & Risk Management : 1~6

[journal] 장문석 / 2008 / Acute Oral Toxicity of Taeumjowi-tang in SD Rats / 동의생리병리학회지 / 한의병리학회 22(6) : 1439~1443

[journal] 진용희 / 2010 / Influence of Prescribed Gamitaeeumjowi-tang on Liver Function : Prospective Single-center Pilot Study / 한방비만학회지 / 한방비만학회 10(1) : 29~40

[journal] 김효정 / 2008 / Clinical Report about the Adverse Reactions of TaeeuminㆍSoeuminㆍSoyangin by Taeeumjowi-tang / 동의생리병리학회지 / 한의병리학회 22(6) : 1600~1605

[journal] 조가원 / 2017 / Review on the Efficacy and Safety of Mahuang and Ephedrine in the Treatment of Obesity -Focused on RCT- / 대한한의학회지 / 대한한의학회 38(3) : 170~184

[journal] Jang IS / 2007 / The need for clinical practice guidelines in usage of Mahuang in weight loss / J Korean Med Obes Res 7(1) : 23~29

[journal] Shekelle PG / 2003 / Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis / JAMA 289(12) : 1537~1545

[journal] Boozer CN / 2002 / Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial / Int J Obes Relat Metab Disord 26(5) : 593~604

[journal] Greenway FL / 1999 / Pharmaceutical cost savings of treating obesity with weight loss medications / Obes Res 7(6) : 523~531

[journal] Christensen P / 2011 / Comparison of a low-energy diet and a very low-energy diet in sedentary obese individuals: a pragmatic randomized controlled trial / Obes 1(1) : 31~40

[journal] Yancy WS Jr / 2004 / A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial / Ann Intern Med 140(10) : 769~777

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Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43

Analysis of Adverse Events in Weight Loss Program in Combination with ‘Gamitaeeumjowee-Tang’ and Low-Calorie Diet

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* References for papers published after 2023 are currently being built.

Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43

Analysis of Adverse Events in Weight Loss Program in Combination with ‘Gamitaeeumjowee-Tang’ and Low-Calorie Diet

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KEYWORDS

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