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@article{ART002667307},
author={Su Min Jung and Young Hyun Seol and Ka Yoon Chun and Min Ha Park and Yi Liu and Seok Yong Kang and Yong-Ki Park and Hyo Won, Jung},
title={Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2020},
volume={20},
number={2},
pages={69-77},
doi={10.15429/jkomor.2020.20.2.69}

TY - JOUR
AU - Su Min Jung
AU - Young Hyun Seol
AU - Ka Yoon Chun
AU - Min Ha Park
AU - Yi Liu
AU - Seok Yong Kang
AU - Yong-Ki Park
AU - Hyo Won, Jung
TI - Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice
JO - Journal of Korean Medicine for Obesity Research
PY - 2020
VL - 20
IS - 2
PB - The Society of Korean Medicine for Obesity Research
SP - 69
EP - 77
SN - 1976-9334
AB - Objectives: In this study, we investigated the antiobesity and antidiabetic effects of polyherbal extract, DM2 consisting of Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in high fat diet-induced obesity mice. Methods: DM2 extract was prepared with a hot water. Six-week-old male C57BL/6N mice were fed a high-fat diet (HFD) for 8 weeks and then administrated with DM2 extract (500 mg/kg, p.o.) for 4 weeks. The changes of physiological markers, body weight (BW), food and water intakes, and the levels of fasting blood glucose (FBG) were measured once a week for 4 weeks in mice. The the serum levels of glucose, insulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (T-CHO), triglyceride, and low density lipoprotein cholesterol in sera were measured in mice using autometic chemical analyzer and enzyme linked immunosorbant assay. We also observed the histological changes of liver and pancreatic tissues with Hematoxylin & Eosin staining. Results: In physiological change, the increases of BW, calorie intake, and FBG in HFD-induced obese mice were significantly decreased after administration of DM2 extract for 4 weeks. The decrease of water intake was significantly increased in DM2 extract-administrated mice. In serological change, the administration of DM2 extract in obesity mice was significantly decreased the serum levels of glucose, insulin, T-CHO, AST, and ALT levels. We also found that DM2 extract inhibited the increase of lipid droplets in liver and the structural destruction of pancreatic tissues in obesity mice. Conclusion: Our study demonstrated that DM2 extract has antiobesity antidiabetic effects with body weight loss, decrease of glucose and insulin levels, and lipid accumulation on liver tissue.
KW - Obesity;Diabetes mellitus;High-fat diet;Atractylodis Rhizoma;Anemarrhenae Rhizoma;Cinnamomi cortex;Moutan radicles cortex
DO - 10.15429/jkomor.2020.20.2.69
ER -

Su Min Jung, Young Hyun Seol, Ka Yoon Chun, Min Ha Park, Yi Liu, Seok Yong Kang, Yong-Ki Park and Hyo Won, Jung. (2020). Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice. Journal of Korean Medicine for Obesity Research, 20(2), 69-77.

Su Min Jung, Young Hyun Seol, Ka Yoon Chun, Min Ha Park, Yi Liu, Seok Yong Kang, Yong-Ki Park and Hyo Won, Jung. 2020, "Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice", Journal of Korean Medicine for Obesity Research, vol.20, no.2 pp.69-77. Available from: doi:10.15429/jkomor.2020.20.2.69

Su Min Jung, Young Hyun Seol, Ka Yoon Chun, Min Ha Park, Yi Liu, Seok Yong Kang, Yong-Ki Park, Hyo Won, Jung "Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice" Journal of Korean Medicine for Obesity Research 20.2 pp.69-77 (2020) : 69.

Su Min Jung, Young Hyun Seol, Ka Yoon Chun, Min Ha Park, Yi Liu, Seok Yong Kang, Yong-Ki Park, Hyo Won, Jung. Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice. 2020; 20(2), 69-77. Available from: doi:10.15429/jkomor.2020.20.2.69

Su Min Jung, Young Hyun Seol, Ka Yoon Chun, Min Ha Park, Yi Liu, Seok Yong Kang, Yong-Ki Park and Hyo Won, Jung. "Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice" Journal of Korean Medicine for Obesity Research 20, no.2 (2020) : 69-77.doi: 10.15429/jkomor.2020.20.2.69

Su Min Jung; Young Hyun Seol; Ka Yoon Chun; Min Ha Park; Yi Liu; Seok Yong Kang; Yong-Ki Park; Hyo Won, Jung. Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice. Journal of Korean Medicine for Obesity Research, 20(2), 69-77. doi: 10.15429/jkomor.2020.20.2.69

Su Min Jung; Young Hyun Seol; Ka Yoon Chun; Min Ha Park; Yi Liu; Seok Yong Kang; Yong-Ki Park; Hyo Won, Jung. Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice. Journal of Korean Medicine for Obesity Research. 2020; 20(2) 69-77. doi: 10.15429/jkomor.2020.20.2.69

Su Min Jung, Young Hyun Seol, Ka Yoon Chun, Min Ha Park, Yi Liu, Seok Yong Kang, Yong-Ki Park, Hyo Won, Jung. Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice. 2020; 20(2), 69-77. Available from: doi:10.15429/jkomor.2020.20.2.69

Su Min Jung, Young Hyun Seol, Ka Yoon Chun, Min Ha Park, Yi Liu, Seok Yong Kang, Yong-Ki Park and Hyo Won, Jung. "Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice" Journal of Korean Medicine for Obesity Research 20, no.2 (2020) : 69-77.doi: 10.15429/jkomor.2020.20.2.69