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Application of Optimized Gompertz Algorithm for Estimation of Controlled Drug Release

  • Journal of The Korea Society of Computer and Information
  • Abbr : JKSCI
  • 2014, 19(12), pp.219-225
  • Publisher : The Korean Society Of Computer And Information
  • Research Area : Engineering > Computer Science

Se-woon Choe 1 Woo, Young Woon 2

1동명대학교
2동의대학교

Accredited

ABSTRACT

A Gompertz modeling, sigmoid in shape, is a widely used application for social science, natural science,engineering, and medical research to allow confident approximation and accurate analysis and has beenapplied to estimate an elderly population on aging of population. Due to the high toxicity of currentlyavailable drug delivery vehicles, various efforts have been made to reduce side-effects in clinical fields,but its application to preclinical and clinical studies is limited and there are some difficulties to optimizethe parameters of Gompertz modeling applicable to preclinical studies. Therefore, in this study, we demonstrated the ability of sickle red blood cells loaded by hypotonic dialysis then photosensitized andlight-activated ex vivo for controlled release and simultaneously optimized Gompertz function to evaluatecontrolled drug release properties of photosensitized sickle red blood cells to reduce pain-relatedtreatments in cancer patients.

Citation status

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