This study examined the effects of communication skills, Nunchi Skills, major satisfaction, and metacognition on clinical practice stress among health-related college students. Data were collected through an online survey from January 18 to February 1, 2025. Clinical practice stress showed negative correlations with communication skills (r = −.127, p = .049), major satisfaction (r = −.279, p < .001), and metacognition (r = −.127, p = .049), with major satisfaction being the strongest predictor (β = −.214, p < .009, 11.9% variance explained). These findings suggest that students with higher levels of satisfaction with clinical practice and their major experience lower clinical practice stress, while indicating that clinical practice stress cannot be sufficiently explained by a single factor. Therefore, multidimensional intervention strategies, including programs to enhance clinical practice and major satisfaction, strengthened clinical instruction, peer interaction, and improvements in the clinical practice environment, should be considered.