@article{ART002179547},
author={Lee Mi Ran},
title={Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism},
journal={Journal of The Korea Society of Computer and Information},
issn={1598-849X},
year={2016},
volume={21},
number={12},
pages={139-145}
TY - JOUR
AU - Lee Mi Ran
TI - Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism
JO - Journal of The Korea Society of Computer and Information
PY - 2016
VL - 21
IS - 12
PB - The Korean Society Of Computer And Information
SP - 139
EP - 145
SN - 1598-849X
AB - In this paper, we propose to evaluate the effect of Resistin-like molecule alpha (Retnla) on the expression of transporters involved in modulating concentrations of peripheral cholesterol and plasma high-density lipoprotein (HDL) cholesterol. High levels of blood cholesterol are a well-recognized risk factor for atherosclerosis and are eliminated via the process of reverse cholesterol transport (RCT).
We recently showed that Retnla ameliorates hypercholesterolemia and atherosclerosis by increasing biliary cholesterol secretion, the final step of the process, in low-density lipoprotein receptor-deficient mice. However, the role of Retnla in HDL-mediated cholesterol efflux, initial step of RCT pathway, is not yet clear. To identify cholesterol transport genes regulated by Retnla, we performed an extensive microarray-based gene expression screen using livers from Retnla-overexpressing (Tg) mice and control animals. The most significant change in Retnla-Tg mice was an upregulation of ATP-binding cassette sub-family G member 4 (Abcg4) transport and was validated using quantitative RT-PCR. The validated gene was also induced by treatment of purified Retnla protein in RAW 264.7 cells incubated with acetylated low-density lipoprotein and Hepa1c1c7 cells. Taken together, these results indicates that Retnla might also accelerate initial step of RCT pathway, suggesting therapeutic value of Retnla in the treatment of hypercholesterolemia and atherosclerosis.
KW - Resistin-like molecule alpha;Atherosclerosis;Reverse cholesterol transport;Hypercholesterolemia;High-density lipoprotein
DO -
UR -
ER -
Lee Mi Ran. (2016). Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism. Journal of The Korea Society of Computer and Information, 21(12), 139-145.
Lee Mi Ran. 2016, "Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism", Journal of The Korea Society of Computer and Information, vol.21, no.12 pp.139-145.
Lee Mi Ran "Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism" Journal of The Korea Society of Computer and Information 21.12 pp.139-145 (2016) : 139.
Lee Mi Ran. Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism. 2016; 21(12), 139-145.
Lee Mi Ran. "Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism" Journal of The Korea Society of Computer and Information 21, no.12 (2016) : 139-145.
Lee Mi Ran. Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism. Journal of The Korea Society of Computer and Information, 21(12), 139-145.
Lee Mi Ran. Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism. Journal of The Korea Society of Computer and Information. 2016; 21(12) 139-145.
Lee Mi Ran. Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism. 2016; 21(12), 139-145.
Lee Mi Ran. "Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism" Journal of The Korea Society of Computer and Information 21, no.12 (2016) : 139-145.
