@article{ART003048172},
author={Mee-Kyung Kim},
title={Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes},
journal={Journal of The Korea Society of Computer and Information},
issn={1598-849X},
year={2024},
volume={29},
number={1},
pages={187-194},
doi={10.9708/jksci.2024.29.01.187}
TY - JOUR
AU - Mee-Kyung Kim
TI - Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes
JO - Journal of The Korea Society of Computer and Information
PY - 2024
VL - 29
IS - 1
PB - The Korean Society Of Computer And Information
SP - 187
EP - 194
SN - 1598-849X
AB - In this study, we examined the effects of Rubus crataegifolius leaf on the inhibition of differentiation and adipogenesis of 3T3-L1 preadipocytes to confirm their potential for use as an anti-obesity functional material. Rubus crataegifolius leaves water extracted using hot water were then concentrated for use, with an extract yield of 4.76%. The result of measuring the rate of 3T3-L1 cell survival of Rubus crataegifolius leaf extract (RCLE) showed growth inhibition of 13% at a concentration of 1,000 μg/mL.
Thus, in this study, experiments were performed using RCLE treatment concentrations up to 500 μg/mL.
Production of triglycedie in 3T3-L1 cells showed a dose-dependent decrease, and the rate of reduction was 28.7, 40.8, and 51.6% at concentrations of 100, 300, and 500 μg/mL, respectively, compared to the control group. In addition, the results confirmed that suppression of lipogenesis was achieved by suppressing the expression of peroxisome proliferator-activated receptor γ (PPAR γ), CCAAT/ enhancer-binding protein α (C/EBP α), sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), and increasing the expression of p-activated protein kinase (p-AMPK). Based on these results, it is believed that Rubus crataegifolius leaf extract can be used in the effort to manage obesity by regulating factors related to adipocyte differentiation and adipogenesis.
KW - Adipocytes differentiation;Adipogenesis;Anti-obesity;Rubus crataegifolius leaf;3T3-L1
DO - 10.9708/jksci.2024.29.01.187
ER -
Mee-Kyung Kim. (2024). Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes. Journal of The Korea Society of Computer and Information, 29(1), 187-194.
Mee-Kyung Kim. 2024, "Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes", Journal of The Korea Society of Computer and Information, vol.29, no.1 pp.187-194. Available from: doi:10.9708/jksci.2024.29.01.187
Mee-Kyung Kim "Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes" Journal of The Korea Society of Computer and Information 29.1 pp.187-194 (2024) : 187.
Mee-Kyung Kim. Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes. 2024; 29(1), 187-194. Available from: doi:10.9708/jksci.2024.29.01.187
Mee-Kyung Kim. "Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes" Journal of The Korea Society of Computer and Information 29, no.1 (2024) : 187-194.doi: 10.9708/jksci.2024.29.01.187
Mee-Kyung Kim. Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes. Journal of The Korea Society of Computer and Information, 29(1), 187-194. doi: 10.9708/jksci.2024.29.01.187
Mee-Kyung Kim. Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes. Journal of The Korea Society of Computer and Information. 2024; 29(1) 187-194. doi: 10.9708/jksci.2024.29.01.187
Mee-Kyung Kim. Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes. 2024; 29(1), 187-194. Available from: doi:10.9708/jksci.2024.29.01.187
Mee-Kyung Kim. "Inhibitory Effects of Rubus crataegifolius Leaf Water Extract on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes" Journal of The Korea Society of Computer and Information 29, no.1 (2024) : 187-194.doi: 10.9708/jksci.2024.29.01.187
