@article{ART002648435},
author={Park Ju-sik and Park Jin-han},
title={Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells},
journal={Kinesiology },
issn={2435-0702},
year={2017},
volume={2},
number={1},
pages={17-23}
TY - JOUR
AU - Park Ju-sik
AU - Park Jin-han
TI - Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells
JO - Kinesiology
PY - 2017
VL - 2
IS - 1
PB - Northeast Asian Studies Journal Institute (J-INSTITUTE)
SP - 17
EP - 23
SN - 2435-0702
AB - It has been reported that Cynanchum wilfordii exhibits anti-oxidant, and anti-cancer activities. However, little is known about biological activity of cynanchone A, an acetophenone isolated from C. wilfordii. In the present study, we investigated the anti-inflammatory effect and the underlying molecular mechanisms of cynanchone A in lipopolysaccharide(LPS)-induced RAW 264.7 cells. During the LPS-induced inflammatory process in RAW 264.7 macrophages, nitric oxide(NO) and prostaglandin E2(PGE2) productions increased. Cynanchone A significantly decreased the protein levels of NO and PGE2 in LPS-treated RAW 264.7 macrophages. Moreover, cynanchone A significantly reduced the elevated the expression levels of inducible nitric oxide(iNOS), cyclooxygenase-2(COX-2) and tumor necrosis factor-a(TNF-a) in LPS-stimulated RAW264.7 cells. Consequently, cynanchone A exerted an anti-inflammatory action through inhibiting nuclear factor-kappa B(NF-κB) activation. Taken together, our results show that the anti-inflammatory properties of cyanchone A are involved in the down-regulating pro-inflammatory cytokines and regulating NF-kB signal pathway in LPS-stimulated RAW264.7 cells.
KW - Cynanchum Wilfordii;RAW264.7;Anti-Inflammatory;Anti-Oxidant;Cyanchone A
DO -
UR -
ER -
Park Ju-sik and Park Jin-han. (2017). Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells. Kinesiology , 2(1), 17-23.
Park Ju-sik and Park Jin-han. 2017, "Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells", Kinesiology , vol.2, no.1 pp.17-23.
Park Ju-sik, Park Jin-han "Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells" Kinesiology 2.1 pp.17-23 (2017) : 17.
Park Ju-sik, Park Jin-han. Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells. 2017; 2(1), 17-23.
Park Ju-sik and Park Jin-han. "Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells" Kinesiology 2, no.1 (2017) : 17-23.
Park Ju-sik; Park Jin-han. Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells. Kinesiology , 2(1), 17-23.
Park Ju-sik; Park Jin-han. Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells. Kinesiology . 2017; 2(1) 17-23.
Park Ju-sik, Park Jin-han. Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells. 2017; 2(1), 17-23.
Park Ju-sik and Park Jin-han. "Anti-Inflammatory Effect of Cynanchone a in Lipopolysaccharide-Induced RAW 264.7 Cells" Kinesiology 2, no.1 (2017) : 17-23.
