Effect of Smoking on Osteoporotic Vertebral Fracture in Postmenopausal Women (폐경 후 여성에서 흡연이 골다공증성 척추 골절에 미치는 영향)

윤상필; Seung-Hwan Lee (이승환); Byeong-Mun Park (박병문); Kyung-Sub Song (송경섭); 장근; Beom-Seok Lee (이범석); HWAN MO LEE (이환모); seong hwan moon (문성환)

Effect of Smoking on Osteoporotic Vertebral Fracture in Postmenopausal Women

Journal of Korean Society of Spine Surgery
Abbr : J Kor Spine Sur
2016, 23(1), pp.1-6
Publisher : Korean Society Of Spine Surgery
Research Area : Medicine and Pharmacy > Orthopedic Surgery

윤상필 ¹, Seung-Hwan Lee ¹, Byeong-Mun Park ², Kyung-Sub Song ¹, 장근 ¹, Beom-Seok Lee ¹, HWAN MO LEE ³, seong hwan moon ³

¹광명성애병원 정형외과
²광명 성애병원 정형외과
³연세대학교

Accredited

ABSTRACT

Study Design: A retrospective study. Objectives: To evaluate the association between smoking and osteoporotic vertebral fractures (OVFs) in postmenopausal women. Summary of Literature Review: Several studies have examined the relationship of smoking with hip fractures, but few studies have analyzed the relationship of smoking with spine fractures in women thus far. Materials and Methods: This study considered 1255 postmenopausal women aged 50 years and older (enrollment from April 2008 to January 2009) from 62 study sites in a nationwide hospital. The amount of smoking was calculated in pack-years. Further, OVFs were diagnosed using a semi-quantitative method. To analyze the relationship between smoking and OVFs, we used a paired t-test, a χ2-test, and a binary logistic regression analysis. Results: The past history of smoking was 7.2% in the patient group and 4.3% in the control group (p=0.025). The mean pack-years of smoking was 0.34 in the control group and 0.62 in the patient group (p=130). The mean T-score in the lumbar bone mass density (BMD) was –1.64 in the control group and –2.19 in the patient group (p=0.409). Smoking was a risk factor of vertebral fractures in postmenopausal women (odd’s ratio=1.68, 95% confidence interval=1.020–2.759, p=0.042) irrespective of the lumbar BMD and the medical treatment for osteoporosis and obesity. Conclusions: Smoking is a risk factor for osteoporotic vertebral fractures in postmenopausal women independently without regard to lumbar BMD. Therefore, cessation of smoking is important for the prevention of OVFs in postmenopausal women.

KEYWORDS

Osteoporotic vertebral fracture, smoking, bone mineral density

Citation status

* References for papers published after 2023 are currently being built.

[journal] Kim KH / 2013 / Secondhand smoke exposure and osteoporosis in never-smoking postmenopausal women: the Fourth Korea National Health and Nutrition Examination Survey / Osteoporos Int 24 : 523~532

[journal] Kanis JA / 2005 / Smoking and fracture risk: a meta-analysis / Osteoporos Int 16 : 155~162

[journal] Law MR / 1997 / A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect / BMJ 315 : 841~846

[journal] Vestergaard P / 2003 / Fracture risk associated with smoking: a meta-analysis / J Intern Med 254 : 572~583

[journal] Ensrud KE / 1997 / Weight change and fractures in older women. Study of Osteoporotic Fractures Research Group / Arch Intern Med 157 : 857~863

[journal] Felson DT / 1993 / Effects of weight and body mass index on bone mineral density in men and women: the Framingham study / J Bone Miner Res 8 : 567~573

[journal] Hemenway D / 1994 / Risk factors for wrist fracture: effect of age, cigarettes, alcohol, body height, relative weight, and handedness on the risk for distal forearm fractures in men / Am J Epidemiol 140 : 361~367

[journal] Williams AR / 1982 / Effect of weight, smoking, and estrogen use on the risk of hip and forearm fractures in postmenopausal women / Obstet Gynecol 60 : 695~699

[journal] Brot C / 1999 / The influence of smoking on vitamin D status and calcium metabolism / Eur J Clin Nutr 53 : 920~926

[journal] Jensen J / 1985 / Cigarette smoking, serum estrogens, and bone loss during hormonereplacement therapy early after menopause / N Engl J Med 313 : 973~975

[journal] Baron JA / 1995 / The effect of cigarette smoking on adrenal cortical hormones / J Pharmacol Exp Ther 272 : 151~155

[journal] Riebel GD / 1995 / The effect of nicotine on incorporation of cancellous bone graft in an animal model / Spine 20 : 2198~2202

[journal] Genant HK / 1993 / Vertebral fracture assessment using a semiquantitative technique / J Bone Miner Res 8 : 1137~1148

[journal] Kim KH / 2012 / Prevalence, awareness, and treatment of osteoporosis among Korean women: The Fourth Korea National Health and Nutrition Examination Survey / Bone 50 : 1039~1047

[journal] Johnell O / 2006 / An estimate of the worldwide prevalence and disability associated with osteoporotic fractures / Osteoporos Int 17 : 1726~1733

[journal] Tanko LB / 2004 / An update on the antiestrogenic effect of smoking: a literature review with implications for researchers and practitioners / Menopause 11 : 104~109

[journal] Rothem DE / 2009 / Nicotine modulates bone metabolism-associated gene expression in osteoblast cells / J Bone Miner Metab 27 : 555~561

[journal] Broulik PD / 2007 / The effect of chronic nicotine administration on bone mineral content and bone strength in normal and castrated male rats / Horm Metab Res 39 : 20~24

[journal] Kaufman DW / 1980 / Cigarette smoking and age at natural menopause / Am J Public Health 70 : 420~422

[journal] Svendsen OL / 1995 / Impact of soft tissue on in vivo accuracy of bone mineral measurements in the spine, hip, and forearm: a human cadaver study / J Bone Miner Res 10 : 868~873

[journal] / 1998 / Osteoporosis: review of the evidence for prevention, diagnosis and treatment and cost-effectiveness analysis. Introduction / Osteoporos Int 8(Suppl 4) : S7~S80

[journal] Cornuz J / 1999 / Smoking, smoking cessation, and risk of hip fracture in women / Am J Med 106 : 311~314

[journal] Hoidrup S / 2000 / Tobacco smoking and risk of hip fracture in men and women / Int J Epidemiol 29 : 253~259

KJCKorea
Journal Central

Journal of Korean Society of Spine Surgery 2023 KCI Impact Factor : 0.03