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1. This manuscript is original and there is no copyright problem, defamation and privacy intrusion. Any legal or ethical damage should not be directed to the Journal of Alternative to Animal Experiments due to this manuscript.


2. All authors contributed to this manuscript actually and intellectually and have responsibility equally to this manuscript.


3. This manuscript was not published or considered for publication to any other scientific journals in the world. It will not be submitted again to other journals without permission from the Journal of Alternative to Animal Experiments if it is accepted for publication.


4. Copyright of this manuscript shall be transferred to the Journal of Alternative to Animal Experiments if it is published in Journal of Alternative to Animal Experiments. It means that if any persons, including authors want to use the contents of this manuscript, they should receive the permission from the Society and the source of contents should be clarified.