Objectives: This study aimed to evaluate the clinical efficacy and safety of Sasang constitutional prescriptions, specifically for the Taeeum type, combined with a low-carbohydrate diet (LCD) in overweight and obese patients.
Methods: This retrospective multi-center chart review first analyzed prescription frequencies among 991 patients (3,020 prescriptions). For efficacy and safety analysis, 590 patients (BMI ≥ 23 ㎏/㎡) treated for ≥ 12 weeks were included. Changes in body composition (n=590), HbA1c (n=153), liver/renal function (n=108), and vital signs (n=446) were compared before and after treatment.
Results: Taeumjowi-tang was prescribed to 63.8% (632/991) of patients, comprising 61.5% (1,858/3,020) of total prescriptions. Among the 590 patients with a BMI ≥ 23 ㎏/㎡ treated for ≥ 12 weeks, body weight and BMI decreased by 7.99±7.15 ㎏ and 2.46±2.71 ㎏/㎡, respectively. Body fat mass accounted for 84% of the weight loss. Post-treatment data showed decreases in HbA1c, liver enzymes (AST, ALT, GGT), and blood pressure, while renal markers (BUN, Creatinine, eGFR) remained unchanged. Heart rate showed a slight increase, which may be related to sympathomimetic components of the prescription.
Conclusions: Sasang constitutional treatment for Taeeum type patients is an effective and generally well-tolerated intervention for weight reduction and metabolic health improvement. Integrating herbal medicine with LCD provides a comprehensive therapeutic strategy for managing obesity and its comorbidities in clinical practice.