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The Effects of Hyeongbangjihwang-tang and Sibimikwanjung-tang in Glycerol-Induced Renal Failure in Rats

  • Journal of Sasang Constitution and Immune Medicine
  • Abbr : JSCIM
  • 2005, 17(3), pp.103~112
  • Publisher : The Society of Sasang Constitution and Immune Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

이형선 1 Kim Il Hwan 1 Kim Hyo Soo 1

1동신대학교

Candidate

ABSTRACT

1.Objective:The present author have examined the comparative effects of Hyeongbangjihwang-tang and Sibimikwanjung-tang in glycerol-induced acute renal failure, a model for myoglobinuric acute renal failure. 2. Methods : Above two prescriptions were applied to rat ad libitum and serum level of creatinine, glucose and blood urea nitrogen(BUN) were measured. And serum level of Na+, K+ and Cl-, too. 50%(vol/vol) glycerol at a dose of 10 ㎖/㎏ of rat body weight intramuscularly and 1% concentration of prescriptions were applied to rats for 7 days ad libitum. 3. Results : Serum level of creatinine and K+ significantly increased by glycerol injection, and these showed pre-renal and renal cause of acute renal failure. Hyeongbangjihwang-tang administered group showed decreasing tendency on serum level of creatinine when compared with control groups, but not significant. Sibimikwanjung-tang administered group showed significant increase of serum level of BUN when compared with control groups. 4. Conclusions : Above two prescriptions showed no significant changes on glycerol induced acute renal failure, but Hyeongbangjihwang-tang and Sibimikwanjung-tang showed a little different manner of response.

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