Anti-inflammatory Activities of Herbal Formulas for Sasang Constitutional Medicine (사상 체질 처방의 항염증 효능 비교 연구 )

이진아; 하혜경; 이호영; 정다영; 이준경; 황대선; 신현규

Anti-inflammatory Activities of Herbal Formulas for Sasang Constitutional Medicine

Journal of Sasang Constitution and Immune Medicine
Abbr : JSCIM
2010, 22(4), pp.56~64
Publisher : The Society of Sasang Constitution and Immune Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

이진아 ¹, 하혜경 ¹, 이호영 ¹, 정다영 ¹, 이준경 ¹, 황대선 ¹, 신현규 ¹

¹한국한의학연구원 표준화연구본부 한약EBM연구센터

Accredited

ABSTRACT

1. Objectives 4 herbal formulas (Yanggyeoksanhwa-tang, Yeoldahanso-tang, Cheongsimyeonja-tang and Taeeumjowi-tang) were applied to investigate the anti-inflammatory activities. In many studies, plant-derived anti-inflammatory efficacies have been investigate for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory activities of 4 herbal formulas on LPS-stimulated RAW 264.7 cells. 2. Methods The productions of nitric oxide (NO), prostaglandin (PG)E2, interleukin(IL)-6 and tumor necrosis factor (TNF)-α were examined in the presence of the 4 herbal formulas in RAW 264.7 cells. The cells were incubated with LPS 1 μg/mL and 4 herbal formulas for 18 hrs. The anti-inflammatory activity of 4 herbal formulas were investigate by carrageenin-induced paw edema in rats. The paw volume was measured at 2 and 4 hrs following carrageenin- induced paw edema in rats. 3. Results Yanggyeoksanhwa-tang and Cheongsimyeonja-tang showed inhibitory effect on PGE2 production in LPS-stimulated RAW 264.7 cells and a reduction in carrageenin-induced paw edema on rats. Yanggyeoksanhwa-tang showed inhibi- tory effect on IL-6 in LPS-stimulated RAW 264.7 cells. 4 herbal formulas not affect on NO and TNF-α inhibition in LPS-stimulated RAW 264.7 cells. 4. Conclusions These results suggested that Yanggyeoksanhwa-tang and Cheongsimyeonja-tang have anti-inflammatory activity.

KEYWORDS

Yanggyeoksanhwa-tang (Lianggesanhuo-tang), Yeoldahanso-tang (Reduohanshao-tang), Cheongsimyeonja-tang (Qingxinlianzi-tang), Taeeumjowi-tang (Taiyintiaowei-tang), Anti-inflammation

Journal Copyright Policy

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Citation status

* References for papers published after 2025 are currently being built.

[book] Dept. of Sasang constitutional medicine / 2006 / Sasang Constitutional Medicine / Gibmundang : 347~420

[journal] Lo HS / 2004 / The effect of Yangkyuk-Sanhwa-Tang on cytokine production in the patients with cerebral infarction / J Sasang Constitut Med 16(1) : 120~129

[journal] 최동준 / 2004 / The Clinical Efficacy of Yangkyuksanwha-tang on Acute Stroke / 대한한의학회지 / 대한한의학회 25(1) : 111~116

[journal] 정성일 / 2002 / Clinical Study about the Diabetes Mellitus Patients Administration of Yangkyuksanwha-tang / 동의생리병리학회지 / 대한동의병리학회 16(6) : 37~1313

[journal] Yun BH / 2004 / Yangkyuksanhwa-tang effected to atopic dermatitis / J Sasang Constitut Med 16(2) : 84~98

[journal] Choi JS / 2001 / Studies on the cytokine production regulation in human astrocytes by Yuldahansotang / J Sasang Constitut Med 13(1) : 61~69

[journal] 김태환 / 2007 / The Effects of Constant Use of Yeoldahanso-tang on Liver Function / 사상체질의학회지 / 사상체질의학회 19(3) : 217~226

[journal] 임종필 / 2007 / The Anti-oxidative and Immune-regulatory Effectof Chungsimyeonja-tang in Aged Rat / 사상체질의학회지 / 사상체질의학회 19(3) : 227~241

[journal] Park SC / 2003 / Effects CheongSimYeonJaTang(CSYJT) on control of immune-function in highly purified mouse B cells and Mast cell / J Sasang Constitut Med 15(2) : 166~179

[journal] 주입산 / 2005 / Studies of Cheongsimyeonja-tang and Taeeumjowi-tang that Get Change by Wistar Rat's Aging / 사상체질의학회지 / 사상체질의학회 17(2) : 74~84

[journal] 김길수 / 2007 / Anti-obesity and Anti-hyperlipidemic Effects of Taeyeumjowee-tang and its modified prescription / 동의신경정신과학회지 / 대한한방신경정신과학회 18(2) : 57~74

[book] Lee JM / 1992 / Dongeuisusebowon / Yeogang Publishing Co. : 271~272

[journal] Yun BH / 2004 / Yangkyuksanhwa-tang effected to atopic dermatitis / J Sasang Constitut Med 16(2) : 84~98

[book] Won JS / 1926 / Dongeuisasangshinpyeon / Munw- oosa : 2~

[journal] Posadas I / 2000 / Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation / Naunyn Schmiedebergs Arch Pha 361(1) : 98~106

[journal] Tae Hoon Lee / 2007 / Methanol Extracts of Stewartia koreana Inhibit Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (iNOS) Gene Expression by Blocking NF-κB Transactivation in LPS-activated RAW 264.7 Cells / 분자와 세포 / 한국분자세포생물학회 23(3) : 398~404

[journal] Nishida T / 2007 / Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB / Dig Dis Sci 52(8) : 1890~1896

[journal] Nathan C / 1994 / Nitric oxide synthases: roles, tolls and controls / Cell 78(6) : 915~918

[journal] McCann SM / 2005 / The nitric oxide theory of aging revisited / Ann N Y Acad Sci 1057 : 64~84

[journal] Kawamata H / 2000 / Enhanced expression of inducible nitric oxide synthases by Juzen-taiho-to in LPS-activated RAW264.7 cells, a murine macrophage cell line / Am J Chin Med 28(2) : 217~226

[journal] Seibert K / 1994 / Pharmacological and biochemical demonstration of the role of cyclooxygenase-2 in inflammation and pain / Proc Natl Acad Sci USA 91(25) : 12013~12017

[journal] Konturek PC / 2005 / Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract / J Physiol Pharmacol S5 : 57~73

[journal] Calixto JB / 2004 / Antiinflammatory compounds of plant origin. Part Ⅱ. modulation of pro-inflammatory cytokines, chemokines and adhesion molecules / Planta Med 70(2) : 92~103

[journal] Duncan GS / 1993 / The local anti-inflammatory action of dexamethasone in the rat carrageenin oedema model is reversed by an antiserum to lipocortin 1 / Br J Pharmacol 108(1) : 62~65

[journal] Wang JP / 1992 / Anti-inflammatory and analgesic effects of magnolol / Naunyn Schmiedebergs Arch Pharmacol 346(6) : 707~712

[journal] Boughton-Smith NK / 1993 / Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat / Br J Pha 110(2) : 896~902

[book] Goodman LS / 1985 / The Pharmacological Basis of Therapeutics. 7th ed / MacMillan : 674~

KJCKorea
Journal Central

Journal of Sasang Constitution and Immune Medicine 2025 KCI Impact Factor : 0.95