@article{ART001509394},
author={서지용 and 최애련 and Koo Deok-Mo},
title={Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats.},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2010},
volume={22},
number={4},
pages={65-76}
TY - JOUR
AU - 서지용
AU - 최애련
AU - Koo Deok-Mo
TI - Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats.
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2010
VL - 22
IS - 4
PB - The Society of Sasang Constitution and Immune Medicine
SP - 65
EP - 76
SN - 1226-4075
AB - 1. Objectives The present study was designed to investigate the effect of Soyangin Hyeongbangdojeok-san(HBDJS) on acute cocaine-induced behavior effect and gene expression in the rat brain.
2. Methods Experimental animals were composed of saline(SAL), cocaine(COC), HBDJS + COC, HBDJS + SAL group. Rats received HBDJS(100, 200 mg/kg, p.o.) 1 h prior to cocaine hydrochloride(20 mg/kg, i.p.) treatment respectively. After cocaine injection, locomotor activity and rearing were measured in a rectangular container equipped with a video camera above the center of the floor for 60 min. In addiction, c-Fos expression in the rat brain was detected using immunohistochemistry 2 h after cocaine injection. And the effect of HBDJS on acute cocaine-induced pERK, pElk, pCREB upstream of c-Fos expression was detected using western blotting and immunohistochemistry 15 min after cocaine challenge.
3. Results The present results show that HBDJS at dose of 200 mg/kg attenuated cocaine-induced both locomotor activity and rearing. Also HBDJS at dose of 200 mg/kg significantly decreased c-Fos expression in the rat brain(nucleus accumebns and striatum). However HBDJS at dose of 200 mg/kg have no effect on cocaine-induced pERK, pCREB, pElK-1 expression. HBDJS is c-Fos expression through ERK-independent pathway.
4. Conclusions.
These results suggest that HBDJS may be effective in suppressing the reinforcing effects of cocaine.
KW - Hyeongbangdojeok-san;Cocaine;Locomotor activity;c-Fos;Nucleus accumbens
DO -
UR -
ER -
서지용, 최애련 and Koo Deok-Mo. (2010). Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats.. Journal of Sasang Constitution and Immune Medicine, 22(4), 65-76.
서지용, 최애련 and Koo Deok-Mo. 2010, "Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats.", Journal of Sasang Constitution and Immune Medicine, vol.22, no.4 pp.65-76.
서지용, 최애련, Koo Deok-Mo "Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats." Journal of Sasang Constitution and Immune Medicine 22.4 pp.65-76 (2010) : 65.
서지용, 최애련, Koo Deok-Mo. Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats.. 2010; 22(4), 65-76.
서지용, 최애련 and Koo Deok-Mo. "Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats." Journal of Sasang Constitution and Immune Medicine 22, no.4 (2010) : 65-76.
서지용; 최애련; Koo Deok-Mo. Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats.. Journal of Sasang Constitution and Immune Medicine, 22(4), 65-76.
서지용; 최애련; Koo Deok-Mo. Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats.. Journal of Sasang Constitution and Immune Medicine. 2010; 22(4) 65-76.
서지용, 최애련, Koo Deok-Mo. Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats.. 2010; 22(4), 65-76.
서지용, 최애련 and Koo Deok-Mo. "Effect of Hyeongbangdojeok-san on Acute Cocaine-induced Behavioral Effect and Immediate Early Gene Expression in Rats." Journal of Sasang Constitution and Immune Medicine 22, no.4 (2010) : 65-76.
