@article{ART001978964},
author={오혜원 and 이지원 and 김제신 and Jun-Hee Lee},
title={Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2015},
volume={27},
number={1},
pages={125-137}
TY - JOUR
AU - 오혜원
AU - 이지원
AU - 김제신
AU - Jun-Hee Lee
TI - Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2015
VL - 27
IS - 1
PB - The Society of Sasang Constitution and Immune Medicine
SP - 125
EP - 137
SN - 1226-4075
AB - ObjectivesThe aim of this study was to investigate clinical factors of SQD syndrome by tracking plasma gut hormone (active ghrelin, active Glucagon-like peptide-1(GLP-1), pancreatic polypeptide(PP), total peptide YY(PYY)) profiling of pre-post prandial standard meal between SQD group and normal group.
MethodsA total of 24 adult participants were consecutively recruited on April 2014. They were diagnosed as either by SQD syndrome or normal by Spleen Qi Deficiency Questionnaire (SQDQ). On the experimental day, blood samplings of 2 ml were repeatedly collected at 6 points from 2 groups for measuring plasma levels of gut hormones. At every point, subjective appetite sensations were self-registered.
Results & Conclusions1. There were significantly lower subjective ‘Appetite’ (p=0.012) and higher ‘Satiety’ (p=0.012) in SQD group. At each time point, subjective ‘Appetite’ was significantly lower at 60 min after breakfast (p=0.034) and ‘Satiety’ were significantly higher at 15 min (p=0.020) and 120 min (p=0.044) after breakfast in SQD group.
2. There were no significant differences in plasma levels of gut hormones (active ghrelin, active GLP-1, PP, total PYY) between SQD and normal group. Also at each time point, there were no significant differences of plasma levels of gut hormones between SQD and normal group.
3. Changes in plasma levels of gut hormones compared to baseline were not significantly different at each time point between SQD and normal group. Plasma PYY levels compared to baseline increased in SQD group following 15 min and 30 min after breakfast but decreased in normal group.
4. Further investigation is needed to construct gut hormone profiling and in this perspective, we can approach evaluation tool on variable appetite in Traditional Korean Medicine (TKM) syndrome in the future.
KW - Spleen Qi Deficiency;Spleen Qi Deficiency Questionnaire;Gut Hormone;Appetite
DO -
UR -
ER -
오혜원, 이지원, 김제신 and Jun-Hee Lee. (2015). Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome. Journal of Sasang Constitution and Immune Medicine, 27(1), 125-137.
오혜원, 이지원, 김제신 and Jun-Hee Lee. 2015, "Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome", Journal of Sasang Constitution and Immune Medicine, vol.27, no.1 pp.125-137.
오혜원, 이지원, 김제신, Jun-Hee Lee "Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome" Journal of Sasang Constitution and Immune Medicine 27.1 pp.125-137 (2015) : 125.
오혜원, 이지원, 김제신, Jun-Hee Lee. Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome. 2015; 27(1), 125-137.
오혜원, 이지원, 김제신 and Jun-Hee Lee. "Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome" Journal of Sasang Constitution and Immune Medicine 27, no.1 (2015) : 125-137.
오혜원; 이지원; 김제신; Jun-Hee Lee. Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome. Journal of Sasang Constitution and Immune Medicine, 27(1), 125-137.
오혜원; 이지원; 김제신; Jun-Hee Lee. Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome. Journal of Sasang Constitution and Immune Medicine. 2015; 27(1) 125-137.
오혜원, 이지원, 김제신, Jun-Hee Lee. Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome. 2015; 27(1), 125-137.
오혜원, 이지원, 김제신 and Jun-Hee Lee. "Exploratory Study on the Pre-and Post-Prandial Subjective Appetite and Plasma Gut Hormone Levels in Spleen Qi Deficiency (SQD) Syndrome" Journal of Sasang Constitution and Immune Medicine 27, no.1 (2015) : 125-137.
