@article{ART002713011},
author={Choi Ji-sook and kim kyung yo and Kim Hyoung-min and Joo, Jong Cheon},
title={Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2001},
volume={13},
number={1},
pages={61-69}
TY - JOUR
AU - Choi Ji-sook
AU - kim kyung yo
AU - Kim Hyoung-min
AU - Joo, Jong Cheon
TI - Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2001
VL - 13
IS - 1
PB - The Society of Sasang Constitution and Immune Medicine
SP - 61
EP - 69
SN - 1226-4075
AB - 사상의학적 견지에서 太陰人의 중풍, 치매와 같은 신경계질환에 다용되고 있는 熱多寒少湯은 최근에 그 임상적 효과를 뒷받침할 다각적인 연구들이 이루어지고 있음에도 불구하고 그 정확한 약리학적 기전에 대해서는 밝혀지지 않고 있다. 본 연구에서는 인간성상세포를 이용하여 熱多寒少湯이 substance P (SP)와 lipopolysaccharide (LPS)에 의해 유도되는 다양한 세포활성물질의 분비량의 조절을 검토함으로써 熱多寒少湯의 약리기전을 면역학적 측면에서 보다 세밀하게 살펴보고자 하였다. 熱多寒少湯 수침액은 인간 뇌 성상세포로 부터 LPS와 SP의 동시자극에 의해 생성되는 세포활성물질중 interleukin (IL)-1, IL-4, IL-6 및 tumor necrosisfaccor-α (TNF-α)의 분비를 농도의존적으로 억제했다. 그러나 interferon-γ (IFN-γ) 및 IL-2의 분비 조절에는 영향을 미치지 않았다. 그리고 항 IL-1β 항체에 의해 SP 유도성 TNF-α 분비의 증가가 억제되기 때문에 IL-1은 TNF-α 증가를 매개하는 역할을 하는 것으로 사료된다. 이상의 결과는 熱多寒少湯에 의한 급성기 중풍환자 치료 효과가 뇌 성상세포로부터 분비되는 세포활성물질의 조절과 밀접한 관련성이 있다는 것을 암시하고 있다.
KW - Yulda-Hanso-Tang;Astrocytes;Tumor necrosis factor-α;Substance P;Lipopolysaccharide;Interleukin-1
DO -
UR -
ER -
Choi Ji-sook, kim kyung yo, Kim Hyoung-min and Joo, Jong Cheon. (2001). Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang. Journal of Sasang Constitution and Immune Medicine, 13(1), 61-69.
Choi Ji-sook, kim kyung yo, Kim Hyoung-min and Joo, Jong Cheon. 2001, "Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang", Journal of Sasang Constitution and Immune Medicine, vol.13, no.1 pp.61-69.
Choi Ji-sook, kim kyung yo, Kim Hyoung-min, Joo, Jong Cheon "Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang" Journal of Sasang Constitution and Immune Medicine 13.1 pp.61-69 (2001) : 61.
Choi Ji-sook, kim kyung yo, Kim Hyoung-min, Joo, Jong Cheon. Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang. 2001; 13(1), 61-69.
Choi Ji-sook, kim kyung yo, Kim Hyoung-min and Joo, Jong Cheon. "Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang" Journal of Sasang Constitution and Immune Medicine 13, no.1 (2001) : 61-69.
Choi Ji-sook; kim kyung yo; Kim Hyoung-min; Joo, Jong Cheon. Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang. Journal of Sasang Constitution and Immune Medicine, 13(1), 61-69.
Choi Ji-sook; kim kyung yo; Kim Hyoung-min; Joo, Jong Cheon. Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang. Journal of Sasang Constitution and Immune Medicine. 2001; 13(1) 61-69.
Choi Ji-sook, kim kyung yo, Kim Hyoung-min, Joo, Jong Cheon. Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang. 2001; 13(1), 61-69.
Choi Ji-sook, kim kyung yo, Kim Hyoung-min and Joo, Jong Cheon. "Studies on the Cytokine Production Regulation in Human Astrocytes by Yuldahansotang" Journal of Sasang Constitution and Immune Medicine 13, no.1 (2001) : 61-69.
