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The Effects of Gunyuljejo-tang on the CCl4-induced Liver Damage in Rats

  • Journal of Sasang Constitution and Immune Medicine
  • Abbr : JSCIM
  • 2004, 16(3), pp.96-107
  • Publisher : The Society of Sasang Constitution and Immune Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : December 31, 2004
  • Accepted : December 31, 2004
  • Published : December 31, 2004

Kim Jung Yul 1 Kim Hyuk 2 Yang Sang Mook 2 Dal Rae Kim 3 Jong Weon Jeon 4

1상지대
2
3경희대학교
4상지대학교

ABSTRACT

1. Objectives This study was carried out to investigate the effects of Gunyuljejo-tang on the CCl4-induced Liver Damage in Rats. 2. Methods Sprague-Dawley rats were devided into 5 experimental groups : Normal, NS+CCl4(Solid extract of CCl4 injection group after Normal Saline feed), GYJJT+CCl4(Solid extract of CCl4 injection group after Gunyuljejo-tang feed), CCl4+NS(Normal Saline feed group after CCl4 injection), CCl4+GYJJT(Solid extract of Gunyuljejo-tang feed group after CCl4 injection). Biochemical assays for serum enzyme activities such as AST, ALT, ALP, BUN, Creatinine, Uric Acid, Total Protein, Albumin, Total Cholesterol, Triglyceride, Glucose, and mRNA Revelation of Cytochrome p450 and activities such as LPO, GSH, GST, Glutathione Reductase, Glutathione Peroxidase, SOD, Catalase, Hydroxyproline, and β-Glucuronidase were performed. 3. Results ① GYJJT+CCl4 showed lower revelation of Cytochrome p450. ②GYJJT+CCl4 showed higher GSH activity than NS+CCl4, CCl4+GYJJT showed higher GSH activity than CCl4+NS injection significantly. ③GYJJT+CCl4 showed higher GST activity than NS+CCl4. CCl4+GYJJT showed higher GST activity than CCl4+NS significantly. ④GYJJT+CCl4 showed higher Glutathione Peroxidase activity than NS+CCl4, CCl4+GYJJT showed higher Glutathione Peroxidase activity than CCl4+NS significantly. ⑤ CCl4+GYJJT showed higher SOD activity than CCl4+NS significantly. ⑥ CCl4+GYJJT showed higher Catalase activity than CCl4+NS significantly. ⑦ GYJJT+CCl4 showed lower Hydroxyproline than NS+CCl4 significantly, CCl4+GYJJT showed higher Hydroxyproline than CCl4+NS significantly. ⑧GYJJT+CCl4 showed higher β-Glucuronidase activity than NS+CCl4, CCl4+GYJJT showed higher β -Glucuronidase activity than CCl4+NS significantly. 4. Conclusions Gunyuljejo-tang has the recovering effects on the CCl4-induced Liver Damage significantly.

Citation status

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