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@article{ART001051236},
author={강민석 and Kim Il Hwan and 김신 and 임치혜 and 초재승 and Kim Hyo Soo and Hye-sun Park and 서은희},
title={An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2007},
volume={19},
number={1},
pages={160-170}

TY - JOUR
AU - 강민석
AU - Kim Il Hwan
AU - 김신
AU - 임치혜
AU - 초재승
AU - Kim Hyo Soo
AU - Hye-sun Park
AU - 서은희
TI - An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2007
VL - 19
IS - 1
PB - The Society of Sasang Constitution and Immune Medicine
SP - 160
EP - 170
SN - 1226-4075
AB - An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts Kang Min-Seok, Kim Shin, Yim Chi-hye, Cho Jae-Seung, Kim Hyo-Soo, Kim Il-Hwan, Park Hye-Sun, Seo Eun Hee* Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-shin Univ*Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Daegu Haany Univ 1. Objectvies This study was performed to find the activities and characteristics of purified thrombolytic enzymes from Holotrichia extracts. 2. Methods In the first time, a coarse enzyme fluid was made by using the freedried Holotrichia extracts. After manufacturing total soluble proteins and purifing enzymes, it was evauluated the activities and characteristics of this enzyme's dissolving capability to fibrin and thrombus. This study was taken using azocasein assay, fibrin-plate method, native-PAGE and fibrin zymography. 3. Results A soluble proteins were efficiently extracted form freezedried Holotrichia extracts. And, this purified enzyme had a ten times fibrinolytic capability compare with ustulation Holotrichia sample. In native PAGE and fibrin zymography, Holotrichia extracts showed the respectable fibrinolytic activity. Also, it had higher thrombolytic activities compared with general thrombolytic enzyme 'plasmin'. In experiment of various protease inhibitors of the purified enzyme from Holotrichia extracts on the azocaseinolytic activity, the enzyme was strongly inhibited by EDTA · EGTA, and weakly by APMSF · PMSF · TPCK. 4. Conclusion Holotrichia extracts has the thrombolytic activities, and it will operate directly th fibrin-clot and thrombus.
KW - Holotrichia;Thrombolysis;Fibrin;Thrombus;Enzyme;Taeum-in
DO -
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ER -

강민석, Kim Il Hwan, 김신, 임치혜, 초재승, Kim Hyo Soo, Hye-sun Park and 서은희. (2007). An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts. Journal of Sasang Constitution and Immune Medicine, 19(1), 160-170.

강민석, Kim Il Hwan, 김신, 임치혜, 초재승, Kim Hyo Soo, Hye-sun Park and 서은희. 2007, "An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts", Journal of Sasang Constitution and Immune Medicine, vol.19, no.1 pp.160-170.

강민석, Kim Il Hwan, 김신, 임치혜, 초재승, Kim Hyo Soo, Hye-sun Park, 서은희 "An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts" Journal of Sasang Constitution and Immune Medicine 19.1 pp.160-170 (2007) : 160.

강민석, Kim Il Hwan, 김신, 임치혜, 초재승, Kim Hyo Soo, Hye-sun Park, 서은희. An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts. 2007; 19(1), 160-170.

강민석, Kim Il Hwan, 김신, 임치혜, 초재승, Kim Hyo Soo, Hye-sun Park and 서은희. "An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts" Journal of Sasang Constitution and Immune Medicine 19, no.1 (2007) : 160-170.

강민석; Kim Il Hwan; 김신; 임치혜; 초재승; Kim Hyo Soo; Hye-sun Park; 서은희. An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts. Journal of Sasang Constitution and Immune Medicine, 19(1), 160-170.

강민석; Kim Il Hwan; 김신; 임치혜; 초재승; Kim Hyo Soo; Hye-sun Park; 서은희. An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts. Journal of Sasang Constitution and Immune Medicine. 2007; 19(1) 160-170.

강민석, Kim Il Hwan, 김신, 임치혜, 초재승, Kim Hyo Soo, Hye-sun Park, 서은희. An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts. 2007; 19(1), 160-170.

강민석, Kim Il Hwan, 김신, 임치혜, 초재승, Kim Hyo Soo, Hye-sun Park and 서은희. "An Experimental Study on the Thrombolytic Activities of Holotrichia Extracts" Journal of Sasang Constitution and Immune Medicine 19, no.1 (2007) : 160-170.