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Effect of Cheongpesagan-tang on the Change of Inhibitory Effect against Lipase Activity and Weight Loss, Plasma and UCP1, 2 mRNA Expression in db/db Mouse

  • Journal of Sasang Constitution and Immune Medicine
  • Abbr : J Sasang Constitut Med
  • 2007, 19(1), pp.171-185
  • Publisher : The Society of Sasang Constitution and Immune Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

Kim Eun-young 1 Kim Hoon 1 Kim Jong Won 1 설유경 1 최재중 1 전수형 1

1동의대학교

Candidate

ABSTRACT

Effect of Cheongpesagan-tang on the Change of Inhibitory Effect against Lipase Activity and Weight Loss, Plasma and UCP1, 2 mRNA Expression in db/db Mouse Eun Young Kim, Yu kyung Sul, Jae Jung Choi, Soo Hyung Jeon, Hoon Kim*, Jong Won Kim Dept. of Sasang Constitution Medicine, College of Oriental Medicine, Dongeui University *Dept. of Oriental Medical History, Dongeui University 1. Objectvies This experimental study was designed to investigate the effect of cheongpesagan-tang extract on the obstruction of the lipase activity and weight, plasma, UCP1, 2 mRNA in db/db mouse. Material and Methods: The body weight loss, food intake, feeding efficiency ratio, weight of the internal organs (liver, kidney, epididymal fat, brown adipose tissue), plasma glucose, triglyceride, total cholesterol, white adipose tissue, adipocyte size distribution, expression of UCP1, 2 mRNA were measured in db/db mouse administered Cheongpesagan-tang extract for 6 weeks. These were then compared with those of control groups administered the diet. 2. Results 1) Inhibitory effect against lipase activity was Kilgyung(81.7%), Nabokja (73.1%), Seungma(73.0%), Daewhang (68.4%), Kalgeun (55.3%), Kobon(34.5%), Hwanggeum(4.2%). 2) In the sample group, the body weight was significantly decrease than that of control group. 3) In the sample group, the weight of epididymal fat showed significantly decrease than that of control group. 4) In the sample group, triglyceride showed significantly decrease than that of control group. 5) In the sample group, distribution of adipose tissue showed significantly larger than that of control group. 6) In the sample group, UCP1, 2 mRNA in BAT showed significantly increase than that of control group. 3. Conclusions These results show that cheongpesagan-tang has an effect on the treatment of obesity.

Citation status

* References for papers published after 2023 are currently being built.