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@article{ART001180134},
author={류정만 and Park Seong-sik},
title={The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2005},
volume={17},
number={2},
pages={64-73}

TY - JOUR
AU - 류정만
AU - Park Seong-sik
TI - The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2005
VL - 17
IS - 2
PB - The Society of Sasang Constitution and Immune Medicine
SP - 64
EP - 73
SN - 1226-4075
AB - 1. Objectives The purpose of this study was to investigate the effects of the enzyme activity of Palmulgunja-tang with administered orally solution on cytochrome P450 isozyme 2. Methods This study was carried on through following methods. We treated the rat with the β-naphthoflavone (βNF) of 80㎎/kg for 3 days i.p injection. Firstable, microsomal protein was separated and total intracellular protein test was done. Then GOT and GPT were measured and assay of cytochrome P450 1A1/2 enzyme activity was performed according to the method of EROD and MROD. (Ethoxyresorufin-O-deethylase(EROD) activity was used to measure cytochrome P450 1A1 activity and  methoxyresorufin O-demethylase(MROD) activity was used to measure  cytochrome P450 1A2 activity. ) 3. Results and Conclusions 1) PGT recovered the liver damage on βNF inducible CYP 1A1/2 by pre-post and high-low condition. 2) At concentration of post-treated 50㎎/kg of PGT, the inhibiting of βNF metabolites to liver of rat cytochrome P450 1A1 was inhibited by 53.0% respectively. 3) PGT showed 36.0% inhibition of βNF-induced 1A2 activity at the concentration post-treated 50㎎/kg.
KW - Palmulgunja-tang;Cytochrome P450 isozyme;Enzyme activity
DO -
UR -
ER -

류정만 and Park Seong-sik. (2005). The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme. Journal of Sasang Constitution and Immune Medicine, 17(2), 64-73.

류정만 and Park Seong-sik. 2005, "The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme", Journal of Sasang Constitution and Immune Medicine, vol.17, no.2 pp.64-73.

류정만, Park Seong-sik "The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme" Journal of Sasang Constitution and Immune Medicine 17.2 pp.64-73 (2005) : 64.

류정만, Park Seong-sik. The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme. 2005; 17(2), 64-73.

류정만 and Park Seong-sik. "The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme" Journal of Sasang Constitution and Immune Medicine 17, no.2 (2005) : 64-73.

류정만; Park Seong-sik. The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme. Journal of Sasang Constitution and Immune Medicine, 17(2), 64-73.

류정만; Park Seong-sik. The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme. Journal of Sasang Constitution and Immune Medicine. 2005; 17(2) 64-73.

류정만, Park Seong-sik. The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme. 2005; 17(2), 64-73.

류정만 and Park Seong-sik. "The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme" Journal of Sasang Constitution and Immune Medicine 17, no.2 (2005) : 64-73.