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@article{ART001339596},
author={Ji Young Lee and Park Seong-sik},
title={The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2009},
volume={21},
number={1},
pages={139-149}

TY - JOUR
AU - Ji Young Lee
AU - Park Seong-sik
TI - The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2009
VL - 21
IS - 1
PB - The Society of Sasang Constitution and Immune Medicine
SP - 139
EP - 149
SN - 1226-4075
AB - 1. Objectives The roots of Sophora flavescens Aiton (SFA) are widely used as a herbal remedy for allergic inflammation. In this study, we invested the effect of SFA on passive cutaneous anaphylaxis reaction and histamin releas and we demonstrated that SFA suppressed the production of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin- 6 (IL-6), and interleukin -8 (IL-8), through inhibition of the NFκB, JNK and p38 pathway in the human mast cell line, HMC-1. 2. Methods To accomplish this, we invested passive cutaneous anaphylaxis reaction and histamin release at an animal experiment. In addition, we investigated the effect of SFA on the production of inflammation-related cytokines in HMC-1 cells that were co-treated with PMA and A23187, which can induce production of pro-inflammatory cytokines. 3. Results and Conclusions SFA induced passive cutaneous anaphylaxis reaction and histamin releas and supressed the expression of TNF-α, IL-6, and IL-8. In addition, the protein levels of TNF-α were also decreased by SFA treatment. Furthermore, SFA inhibited the nuclear translocation of nuclear factor NFκB through inhibition of the phosphorylation and degradation of IκB-α, which is an inhibitor of NFκB. Moreover, SFA also inhibited induction of MAPKs (JNK, p38) and NFκB promoter-mediated luciferase activity. Taken together, these results suggest that SFA could be used as a treatment for mast cell-derived allergic inflammatory diseases.
KW - Sophora flavescens Aiton (SFA);Allergic Inflammation;TNF-α;IL-6;IL-8;MAPKs (JNK;p38);NFκBrn
DO -
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Ji Young Lee and Park Seong-sik. (2009). The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway. Journal of Sasang Constitution and Immune Medicine, 21(1), 139-149.

Ji Young Lee and Park Seong-sik. 2009, "The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway", Journal of Sasang Constitution and Immune Medicine, vol.21, no.1 pp.139-149.

Ji Young Lee, Park Seong-sik "The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway" Journal of Sasang Constitution and Immune Medicine 21.1 pp.139-149 (2009) : 139.

Ji Young Lee, Park Seong-sik. The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway. 2009; 21(1), 139-149.

Ji Young Lee and Park Seong-sik. "The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway" Journal of Sasang Constitution and Immune Medicine 21, no.1 (2009) : 139-149.

Ji Young Lee; Park Seong-sik. The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway. Journal of Sasang Constitution and Immune Medicine, 21(1), 139-149.

Ji Young Lee; Park Seong-sik. The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway. Journal of Sasang Constitution and Immune Medicine. 2009; 21(1) 139-149.

Ji Young Lee, Park Seong-sik. The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway. 2009; 21(1), 139-149.

Ji Young Lee and Park Seong-sik. "The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway" Journal of Sasang Constitution and Immune Medicine 21, no.1 (2009) : 139-149.