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Acute Toxicity Study on Yeoldahanso-tang in Mice

  • Journal of Sasang Constitutional Medicine
  • Abbr : J Sasang Constitut Med
  • 2009, 21(1), pp.247-253
  • Publisher : The Society Of Sasang Constitutional Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

마진열 1 황대선 1 Siwoo Lee 1 김종열 1 신현규 1

1한국한의학연구원

Accredited

ABSTRACT

1. Objectives This study was designed to andyze the acute toxicity and safety of Yeoldahanso-tang. 2. Methods We investigated the acute toxicity for water-extracted Yeoldahanso-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yeoldahanso-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 ㎎/㎏. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Yeoldahanso-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 ㎎/㎏). In conclusion, LD50 of Yeoldahanso-tang was over 5000 ㎎/㎏ and it is very safe to mice.

Citation status

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