Effects of Yuldahanso-tang and Chungsimyonja-tang on Cytochrome P450 Activities (열다한소탕과 청심연자탕의 Cytochrome P450 활성 연구)

Seong Eun Jin (진성은); Hyekyung Ha (하혜경); 신현규

doi:10.7730/JSCM.2012.24.4.84

Effects of Yuldahanso-tang and Chungsimyonja-tang on Cytochrome P450 Activities

Journal of Sasang Constitution and Immune Medicine
Abbr : J Sasang Constitut Med
2012, 24(4), pp.84-91
DOI : 10.7730/JSCM.2012.24.4.84
Publisher : The Society of Sasang Constitution and Immune Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

Seong Eun Jin ¹, Hyekyung Ha ¹, 신현규 ²

¹한국한의학연구원
²한국한의학연구원 한약기초연구그룹

Accredited

ABSTRACT

Objectives The purpose of this study is to investigate the inhibitory or inductive potentials of Yuldahanso-tang (YDT) and Chungsimyonja-tang (CST), herbal formulas for Taeeumin, on cytochrome P450 (CYP450) drug metabolizing enzyme. The mechanisms for the herbal formula-drug interaction has not been well reported in spite of the chance for co-administration with conventional drugs. Methods To evaluate the interaction potential of YDT-drug or CST-drug, the fluorescence-based enzyme assays on CYP450 isozymes including CYP3A4, CYP2C19, CYP2D6 and CYP2E1 were established in vitro. The inhibitory effects of herbal formulas were characterized with IC50 values. Results YDT showed inhibitory effects on CYP2D6 and CYP2E1-mediated metabolism, while it exhibited week inhibition on CYP3A4 and CYP2C19 relatively. CST exerted relatively weak inhibitory effects on the four CYP450 isozymes compared to that of YDT. Conclusions These results suggest that the herbal formula-drug interaction could be occur when YDT are co-administered with drugs mediated by CYP2D6 or CYP2E1.

KEYWORDS

Cytochrome P450, herb-drug interactions, Yuldahanso-tang, Chungsimyonja-tang, Taeeumin

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Journal of Sasang Constitution and Immune Medicine 2023 KCI Impact Factor : 0.42

Effects of Yuldahanso-tang and Chungsimyonja-tang on Cytochrome P450 Activities

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Journal of Sasang Constitution and Immune Medicine 2023 KCI Impact Factor : 0.42

Effects of Yuldahanso-tang and Chungsimyonja-tang on Cytochrome P450 Activities

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