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@article{ART001889436},
author={박근희 and 임태형 and Park Hye Sun},
title={Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice},
journal={Journal of Sasang Constitutional Medicine},
issn={1226-4075},
year={2014},
volume={26},
number={2},
pages={180-193},
doi={10.7730/JSCM.2014.26.2.}

TY - JOUR
AU - 박근희
AU - 임태형
AU - Park Hye Sun
TI - Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice
JO - Journal of Sasang Constitutional Medicine
PY - 2014
VL - 26
IS - 2
PB - The Society Of Sasang Constitutional Medicine
SP - 180
EP - 193
SN - 1226-4075
AB - ObjectivesThe present study was carried out to investigate effects of HBPDS on allergic contact dermatitis (ACD) induced by 2,4-Dinitro-1-fluorobenzene (DNFB) in mice. MethodsIn this experiment, effects of HBPDS on body weights, skin thicknesses, skin weights, histopathological changes, clinical aspects, erythema index, melanin index, production levels of cytokines in ACD mice were investigated. In addition, effects on proliferation rates, release of β-hexosaminidase and histamine were also investigated in vitro. Results & Conclusions1) HBPDS inhibited enlargement of skin thickness and weight significantly (P < 0.05). 2) HBPDS treatment prevented spongiosis, edema and immune cell infiltrations. 3) Erythema, desquamation and keratosis were diminished by oral administration of HBPDS. 4) Production levels of TNF-alpha and IFN-gamma in serum were decreased by HBPDS treatment in vivo. 5) More than 200 ㎍/㎖ of HBPDS treatment decreased β-hexosaminidase release and more than 400 ㎍/㎖ of HBPDS treatment also decreased histamine release in vitro.
KW - Hyeongbangpaedok-san;Allergic Contact Dermatitis;DNFB;Sasang Contitutional Medicine
DO - 10.7730/JSCM.2014.26.2.
ER -

박근희, 임태형 and Park Hye Sun. (2014). Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice. Journal of Sasang Constitutional Medicine, 26(2), 180-193.

박근희, 임태형 and Park Hye Sun. 2014, "Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice", Journal of Sasang Constitutional Medicine, vol.26, no.2 pp.180-193. Available from: doi:10.7730/JSCM.2014.26.2.

박근희, 임태형, Park Hye Sun "Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice" Journal of Sasang Constitutional Medicine 26.2 pp.180-193 (2014) : 180.

박근희, 임태형, Park Hye Sun. Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice. 2014; 26(2), 180-193. Available from: doi:10.7730/JSCM.2014.26.2.

박근희, 임태형 and Park Hye Sun. "Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice" Journal of Sasang Constitutional Medicine 26, no.2 (2014) : 180-193.doi: 10.7730/JSCM.2014.26.2.

박근희; 임태형; Park Hye Sun. Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice. Journal of Sasang Constitutional Medicine, 26(2), 180-193. doi: 10.7730/JSCM.2014.26.2.

박근희; 임태형; Park Hye Sun. Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice. Journal of Sasang Constitutional Medicine. 2014; 26(2) 180-193. doi: 10.7730/JSCM.2014.26.2.

박근희, 임태형, Park Hye Sun. Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice. 2014; 26(2), 180-193. Available from: doi:10.7730/JSCM.2014.26.2.

박근희, 임태형 and Park Hye Sun. "Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice" Journal of Sasang Constitutional Medicine 26, no.2 (2014) : 180-193.doi: 10.7730/JSCM.2014.26.2.