@article{ART002707476},
author={Kim Il-hwan and kim kyung yo},
title={Effects of Yuldahansotang after kainate administration in the mouse hippocampus area},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={1999},
volume={11},
number={2},
pages={283-299}
TY - JOUR
AU - Kim Il-hwan
AU - kim kyung yo
TI - Effects of Yuldahansotang after kainate administration in the mouse hippocampus area
JO - Journal of Sasang Constitution and Immune Medicine
PY - 1999
VL - 11
IS - 2
PB - The Society of Sasang Constitution and Immune Medicine
SP - 283
EP - 299
SN - 1226-4075
AB - 1. Purpose : Systemic injection of kainic acid in experimental animals induces the limbic seizure and structural damages in hippocampus and amygdala which resembles the changes in human temporal lobe epilepsy.
The author performed this study to investigate the neuroprotective effects of Yuldahansotang, on the neurotoxicity induced by kainic acid in the hippocampus in rats.
2. Method : Kainic acid was administered intraperitoneally. And feeding with Yuldahansotang for 3 weeks after kainic acid administration.
Seizure were induced in male mice (kainate 10-40 mg/kg i.p) and animals were sacrified at various time-points after injection. The experimental animals were sacrificed at 1, 2, 3day and 1, 3weeks while Yuldahansotang administrations.
Seizure were graded using a behavioral scale developed in our laboratory.
c-fos belong to immediate early genes(IEGs) known to have rapid and brief responses. And neuronal injury was assayed by examining DNA fragmentation using in situ nick translation histochemistry.
3. Results & Conclusion : Seizure severity paralled kainate dosage.
At higher doses DNA fragmentation is seen mainly in hippocampus in area CA3, and variable in CA1, thalamus, amygdala within 24 h, is maximal within 72 h, and is large gene by 7 days after administration of kainate. And we can't see the expression of DNA fragmentation and c-fos in the mice what feeded by Yuldahansotang after 7 days from kainic acid administration.
It is consequently suggested that Yuldahansotang may attenuate the kainic acid-induced neuronal degeneration and increase the immunoreactivity of hippocampus in mouse.
KW - Yuldahansotang;kainic acid;c-fos protein;DNA fragmentation
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Kim Il-hwan and kim kyung yo. (1999). Effects of Yuldahansotang after kainate administration in the mouse hippocampus area. Journal of Sasang Constitution and Immune Medicine, 11(2), 283-299.
Kim Il-hwan and kim kyung yo. 1999, "Effects of Yuldahansotang after kainate administration in the mouse hippocampus area", Journal of Sasang Constitution and Immune Medicine, vol.11, no.2 pp.283-299.
Kim Il-hwan, kim kyung yo "Effects of Yuldahansotang after kainate administration in the mouse hippocampus area" Journal of Sasang Constitution and Immune Medicine 11.2 pp.283-299 (1999) : 283.
Kim Il-hwan, kim kyung yo. Effects of Yuldahansotang after kainate administration in the mouse hippocampus area. 1999; 11(2), 283-299.
Kim Il-hwan and kim kyung yo. "Effects of Yuldahansotang after kainate administration in the mouse hippocampus area" Journal of Sasang Constitution and Immune Medicine 11, no.2 (1999) : 283-299.
Kim Il-hwan; kim kyung yo. Effects of Yuldahansotang after kainate administration in the mouse hippocampus area. Journal of Sasang Constitution and Immune Medicine, 11(2), 283-299.
Kim Il-hwan; kim kyung yo. Effects of Yuldahansotang after kainate administration in the mouse hippocampus area. Journal of Sasang Constitution and Immune Medicine. 1999; 11(2) 283-299.
Kim Il-hwan, kim kyung yo. Effects of Yuldahansotang after kainate administration in the mouse hippocampus area. 1999; 11(2), 283-299.
Kim Il-hwan and kim kyung yo. "Effects of Yuldahansotang after kainate administration in the mouse hippocampus area" Journal of Sasang Constitution and Immune Medicine 11, no.2 (1999) : 283-299.
