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Inhibitory effects of Yangdokbackhotang on the Immune Hypersensitive Reaction in skin transplant mice

  • Journal of Sasang Constitution and Immune Medicine
  • Abbr : J Sasang Constitut Med
  • 2003, 15(2), pp.151-165
  • Publisher : The Society of Sasang Constitution and Immune Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : August 31, 2003
  • Accepted : August 31, 2003
  • Published : August 30, 2003

Jeon Jun Young 1 Park Seong Sik 2

1동국대학교
2동국대학교 한의과대학 사상체질과

ABSTRACT

Objective: This study was carried out to evaluate the inhibitory effect on immme hypersensitive reaction by Yangdokbackhotang extract. methods: To study, We divided 4 weeks old rats into three groups of 20, which are the constrasive group with nothing treated, the skin transplated only, and the Yangdokbackhotang extract fed before skin transplantation. And did the experiment. Results: 1. The ear swelling in mice treated with YB noticeably decreased than only DNCB treated mice. 2. As shown in Table3, also results in a significant decrease of YB group than ST group in the number of positive cells of NF−κB, COX-2, IL-12B, and ICAM-1. From the above results, it could be concluded that Yangdokbackhotang showed benificial immunosupressive effect on the hypersensitive reaction.

KEYWORDS

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