@article{ART002763745},
author={Song, Seung-Yun and Kim Hyoung-soon and kim kyung yo and Go Gi-Deok and Kim Il Hwan},
title={Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2002},
volume={14},
number={1},
pages={67-78}
TY - JOUR
AU - Song, Seung-Yun
AU - Kim Hyoung-soon
AU - kim kyung yo
AU - Go Gi-Deok
AU - Kim Il Hwan
TI - Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2002
VL - 14
IS - 1
PB - The Society of Sasang Constitution and Immune Medicine
SP - 67
EP - 78
SN - 1226-4075
AB - 調胃升淸湯이 산소자유기에 의한 신경독성을 방어하는 효과를 규명하기 위하여 흰쥐의 태아에서 분리 培養한 海馬神經細胞를 여러 농도의 Xanthine Oxidase(XO)와 Hypoxanthine (HX)이 포함된 培養液에 調胃升淸湯 煎湯液을 3시간 동안 전처리한 다음 調胃升淸湯이 培養 海馬神經細胞에 미치는 영향을 관찰한 결과 다음과 같은 결론을 얻었다. 1. XO/HX는 MTT assay와 NR assay에 의한 세포생존율을 감소시켰고 Lipid peroxidation의 증가 및 DNA synthesis의 감소에 의하여 생쥐의 培養 海馬神經細胞에 독성을 나타냈다. 2. 調胃升淸湯 煎湯液은 XO/HX에 의하여 유발된 Lipid peroxidation을 유의하게 방어하였다. 3. 調胃升淸湯은 XO/HX에 의하여 감소한 DNA synthesis를 유의하게 증가시켰다. 이상의 실험결과는 XO/HX가 흰쥐의 태아에서 분리 培養한 海馬神經細胞에 산화적 손상에 의한 신경독성을 나타냈으며, 調胃升淸湯이 培養한 海馬神經細胞 의 산화적 손상에 대하여 유의성있는 방어적 작용이 나타낸 것으로, 치매등의 임상적 응용에 대해서도 지속적인 연구가 필요하다고 사료된다.
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Song, Seung-Yun, Kim Hyoung-soon, kim kyung yo, Go Gi-Deok and Kim Il Hwan. (2002). Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX. Journal of Sasang Constitution and Immune Medicine, 14(1), 67-78.
Song, Seung-Yun, Kim Hyoung-soon, kim kyung yo, Go Gi-Deok and Kim Il Hwan. 2002, "Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX", Journal of Sasang Constitution and Immune Medicine, vol.14, no.1 pp.67-78.
Song, Seung-Yun, Kim Hyoung-soon, kim kyung yo, Go Gi-Deok, Kim Il Hwan "Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX" Journal of Sasang Constitution and Immune Medicine 14.1 pp.67-78 (2002) : 67.
Song, Seung-Yun, Kim Hyoung-soon, kim kyung yo, Go Gi-Deok, Kim Il Hwan. Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX. 2002; 14(1), 67-78.
Song, Seung-Yun, Kim Hyoung-soon, kim kyung yo, Go Gi-Deok and Kim Il Hwan. "Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX" Journal of Sasang Constitution and Immune Medicine 14, no.1 (2002) : 67-78.
Song, Seung-Yun; Kim Hyoung-soon; kim kyung yo; Go Gi-Deok; Kim Il Hwan. Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX. Journal of Sasang Constitution and Immune Medicine, 14(1), 67-78.
Song, Seung-Yun; Kim Hyoung-soon; kim kyung yo; Go Gi-Deok; Kim Il Hwan. Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX. Journal of Sasang Constitution and Immune Medicine. 2002; 14(1) 67-78.
Song, Seung-Yun, Kim Hyoung-soon, kim kyung yo, Go Gi-Deok, Kim Il Hwan. Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX. 2002; 14(1), 67-78.
Song, Seung-Yun, Kim Hyoung-soon, kim kyung yo, Go Gi-Deok and Kim Il Hwan. "Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX" Journal of Sasang Constitution and Immune Medicine 14, no.1 (2002) : 67-78.
