@article{ART002802163},
author={Lo Hyun Soo and Lee Sang Min and Bae Young Chun and Park Hye Sun and Lee Jae Heung and Song Seung-Yun and Yoo Kwan-Seok and Jong-Cheon Joo},
title={The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2004},
volume={16},
number={1},
pages={120-129}
TY - JOUR
AU - Lo Hyun Soo
AU - Lee Sang Min
AU - Bae Young Chun
AU - Park Hye Sun
AU - Lee Jae Heung
AU - Song Seung-Yun
AU - Yoo Kwan-Seok
AU - Jong-Cheon Joo
TI - The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2004
VL - 16
IS - 1
PB - The Society of Sasang Constitution and Immune Medicine
SP - 120
EP - 129
SN - 1226-4075
AB - Yangkyuk-Sanhwa-Tang(YST) has been widely used as a formula for the Soyangin cerebral infarction (CI) patients according to Sasang constitutional philosophy. Brain cells produce cytokines and chemokines during the inflammatory process after stroke both in animal models and in patients. Previously, regulation of serum cytokine levels by YSThas been observed in individuals at the acute stage of CI disease, but there have not been other scientific investigations on YST. The author investigated the effect of YST on theproduction of various cytokines using peripheral blood mononuclear cells (PBMCs)from the Soyangin (CI) patients, and Soyangin normal group. The cytokine production was analyzed using enzyme-linked immunosorbent assay (ELISA). The amount of interleukin (IL)-1, IL-1, IL-6, IL-8, and tumor necrosis factor (TNF)- in culture supernatant significantly increased in the LPS-treated cells compared with unstimulated-cells (P < 0.05). However, in LPS-stimulated PBMCs, cytokines level in CI patients group was higher than that of normal group. YST (1 mg/ml) significantly inhibited IL-1, IL-1, and IL-8 production in PBMCs stimulated with LPS (about 85% for IL-1, 87% for IL-1, and 53% for IL-8, P < 0.05), but did not significantly inhibit IL-6 and TNF- production in the CI patients group. We also show that YST significantly increased LPS-induced IL-1, IL-6, and TNF- production in the normal group. Thesedata suggest that YST has a regulatoryeffect on the cytokine production, which might explain its beneficial effect in the treatment of CI.
KW - Yangkyuk-Sanhwa-Tang;lipopolysaccharide;cerebral infarction;cytokine
DO -
UR -
ER -
Lo Hyun Soo, Lee Sang Min, Bae Young Chun, Park Hye Sun, Lee Jae Heung, Song Seung-Yun, Yoo Kwan-Seok and Jong-Cheon Joo. (2004). The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction. Journal of Sasang Constitution and Immune Medicine, 16(1), 120-129.
Lo Hyun Soo, Lee Sang Min, Bae Young Chun, Park Hye Sun, Lee Jae Heung, Song Seung-Yun, Yoo Kwan-Seok and Jong-Cheon Joo. 2004, "The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction", Journal of Sasang Constitution and Immune Medicine, vol.16, no.1 pp.120-129.
Lo Hyun Soo, Lee Sang Min, Bae Young Chun, Park Hye Sun, Lee Jae Heung, Song Seung-Yun, Yoo Kwan-Seok, Jong-Cheon Joo "The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction" Journal of Sasang Constitution and Immune Medicine 16.1 pp.120-129 (2004) : 120.
Lo Hyun Soo, Lee Sang Min, Bae Young Chun, Park Hye Sun, Lee Jae Heung, Song Seung-Yun, Yoo Kwan-Seok, Jong-Cheon Joo. The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction. 2004; 16(1), 120-129.
Lo Hyun Soo, Lee Sang Min, Bae Young Chun, Park Hye Sun, Lee Jae Heung, Song Seung-Yun, Yoo Kwan-Seok and Jong-Cheon Joo. "The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction" Journal of Sasang Constitution and Immune Medicine 16, no.1 (2004) : 120-129.
Lo Hyun Soo; Lee Sang Min; Bae Young Chun; Park Hye Sun; Lee Jae Heung; Song Seung-Yun; Yoo Kwan-Seok; Jong-Cheon Joo. The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction. Journal of Sasang Constitution and Immune Medicine, 16(1), 120-129.
Lo Hyun Soo; Lee Sang Min; Bae Young Chun; Park Hye Sun; Lee Jae Heung; Song Seung-Yun; Yoo Kwan-Seok; Jong-Cheon Joo. The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction. Journal of Sasang Constitution and Immune Medicine. 2004; 16(1) 120-129.
Lo Hyun Soo, Lee Sang Min, Bae Young Chun, Park Hye Sun, Lee Jae Heung, Song Seung-Yun, Yoo Kwan-Seok, Jong-Cheon Joo. The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction. 2004; 16(1), 120-129.
Lo Hyun Soo, Lee Sang Min, Bae Young Chun, Park Hye Sun, Lee Jae Heung, Song Seung-Yun, Yoo Kwan-Seok and Jong-Cheon Joo. "The Effect of Yangkyuk-Sanhwa-Tang on Cytokine Production in the Patients with Cerebral Infarction" Journal of Sasang Constitution and Immune Medicine 16, no.1 (2004) : 120-129.
